Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun 28;23(1):e0247.
doi: 10.1097/CLD.0000000000000247. eCollection 2024 Jan-Jun.

Liver biopsy: Archaic but resilient and many roads lead to Rome

K Rajender Reddy  1
Affiliations
Review

Liver biopsy: Archaic but resilient and many roads lead to Rome

K Rajender Reddy. Clin Liver Dis (Hoboken). .
No abstract available

PubMed Disclaimer

Conflict of interest statement

K. Rajender Reddy advises and received grants from Mallinckrodt. He advises Spark Therapeutics, Pfizer, Novo Nordisk, and R2R Pharma. He received grants from BMS, Intercept, Exact Sciences, GSK, Camarus, Grifols, Sequana, HCC-TARGET, and NASH-TARGET. He is on the data safety monitoring board for Genkyotex, HiTide, Novartis, and Astra Zeneca.

Figures

FIGURE 1
FIGURE 1
Four percutaneous needle biopsy devices. (A) Menghini needle, photographs generously provided by Dr Adrian Reuben from his collection, showing a mint 7 cm × 1.6 mm Menghini needle c.1958, complete with skin-piercing stylet (above in the box), the needle (middle in the box) and 3.5-cm “nail” shown partially inserted into the hub, long stylet for expelling biopsy core specimen from the needle (below needle in the box). Dr Reuben received this vintage device as a gift from a gastroenterologist in Connecticut who had trained in Milan. (B) Klatskin needle—a modification of Menghini’s device by Dr Gerald Klatskin, Head of the Liver Study Unit at Yale University. The inset shows sharpening of the needle tip, inside and outside, according to Klatskin. (C) A VIM-Silverman cutting split needle, showing the closed needle itself (middle image), the assembled device (lower image) in which the needle is inserted in the metal sheath, and a metal director (upper image) for removing the biopsy specimen from the needle. Photograph generously provided by Dr Adrian Reuben from his collection. (D) Tru-Cut needle spring-triggered biopsy device, 12 cm × 18 G. (D, needle open) showing 20 mm slot for liver biopsy specimen and (D needle closed) showing needle tip closed, that is, covered with a sheath that has trapped liver sample in needle slot. Photographs generously provided by Dr. Adrian Reuben from his collection.
FIGURE 2
FIGURE 2
Liver biopsy core specimen obtained using a 16-G Klatskin needle. Courtesy of Larry Friedman.
FIGURE 3
FIGURE 3
Endo-hepatology. Courtesy of Dr Mithun Sharma and Dr Anand Kulkarni, India. Spectrum of procedures available through EUS. Abbreviations: EUS, endoscopic ultrasound; RFA, radiofrequency ablation; SOL, space-occupying lesion.
None
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Frerichs FT. U¨ eber den Diabetes. A. Hirschwald; 1884:272.
    1. Sherlock S. Aspiration liver biopsy—Technique and diagnostic application. Lancet. 1945;2:397–401.
    1. Dible J, Michael J, Sherlock S. Pathology of acute hepatitis. Lancet. 1943;ii:402–403.
    1. Sharma OP. The Life of Sheila Sherlock, ‘The Liver Queen ’ Royal College of Physicians London; 2007.
    1. Sherlock S. Disease of the Liver and Biliary System Vol. 3. Blackwell Scientific Publications; 1955:69–81.