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Multicenter Study
. 2024 Jun 17:12:1368401.
doi: 10.3389/fpubh.2024.1368401. eCollection 2024.

Association of diet and outdoor time with inflammatory bowel disease: a multicenter case-control study using propensity matching analysis in China

Xiaotian Chu #  1 , Xuanfu Chen #  1 , Huimin Zhang  1 , Yufang Wang  2 , Hong Guo  3 , Yan Chen  4 , Xiaowei Liu  5 , Zhenhua Zhu  6 , Yao He  7 , Xueli Ding  8 , Qunying Wang  9 , Changqing Zheng  10 , Xiaocang Cao  11 , Hong Yang  1 , Jiaming Qian  1
Affiliations
Multicenter Study

Association of diet and outdoor time with inflammatory bowel disease: a multicenter case-control study using propensity matching analysis in China

Xiaotian Chu et al. Front Public Health. .

Abstract

Objective: To investigate the association between dietary and some other environmental factors and the risk of inflammatory bowel diseases (IBD) in Chinese population.

Materials and methods: A multicenter case-control study was conducted involving 11 hospitals across China. A total of 1,230 subjects were enrolled consecutively, and diet and environmental factor questionnaires were collected. IBD patients were matched with healthy controls (HC) using propensity-score matching (PSM) at a 1:1 ratio with a caliper value of 0.02. Multivariate conditional logistic regression analyses were performed to evaluate the associations between diet, environmental factors, and IBD.

Results: Moderate alcohol and milk consumption, as well as daily intake of fresh fruit, were protective factors for both Crohn's disease (CD) and ulcerative colitis (UC). Conversely, the consumption of eggs and chocolate increased the risk of IBD. Outdoor time for more than 25% of the day was a protective factor only for CD. In eastern regions of China, CD patients had higher egg consumption and less outdoor time, while UC patients consumed more chocolate. IBD patients from urban areas or with higher per capita monthly income consumed more fruit, eggs, and chocolate.

Conclusions: This study reveals an association between specific foods, outdoor time, and the emergence of IBD in the Chinese population. The findings emphasize the importance of a balanced diet, sufficient outdoor time and activities, and tailored prevention strategies considering regional variations.

Keywords: Crohn's disease; case-control study; environmental factors; outdoor time; ulcerative colitis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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