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Case Reports
. 2024 Jul;65(7):643-648.

Inflammatory myofibroblastic tumor in the urinary bladder in a dog

Jiyoung Park #  1 , Sang Gwan Lee #  1 , Seong Mok Jeong  1 , Aryung Nam  1
Affiliations
Case Reports

Inflammatory myofibroblastic tumor in the urinary bladder in a dog

Jiyoung Park et al. Can Vet J. 2024 Jul.

Abstract
in English, French

An 8-year-old castrated male Maltese dog was presented with a urinary bladder mass, urolithiasis, and hematuria. A solitary, pedunculated, intraluminal mass on the caudodorsal wall was identified with extensive irregular bladder wall thickening, and the mass was surgically removed. Postoperative histopathology demonstrated a submucosal lesion comprising spindle cells with marked inflammatory cell infiltration, without malignant changes. Immunohistochemical staining revealed vimentin and desmin positivity in the mass. An inflammatory myofibroblastic tumor (IMT) was definitively diagnosed. No recurrence was observed during a 43-month follow-up period. Although IMTs are rare in dogs, they should be considered a differential diagnosis for mass-like urinary bladder lesions accompanying a chronic inflammatory disease process. Key clinical message: Canine IMT should be included in the differential diagnoses of bladder masses, especially when dogs exhibit chronic irritation and inflammation.

Tumeur myofibroblastique inflammatoire de la vessie chez un chienUn chien maltais mâle castré de 8 ans a été présenté avec une masse à la vessie, une lithiase urinaire et une hématurie. Une masse intraluminale pédonculée solitaire sur la paroi caudodorsale a été identifiée avec un épaississement important et irrégulier de la paroi vésicale, et la masse a été retirée chirurgicalement. L’histopathologie postopératoire a mis en évidence une lésion à la sous-muqueuse comprenant des cellules fusiformes avec une infiltration cellulaire inflammatoire marquée, sans modification maligne. La coloration immunohistochimique a révélé une positivité à la vimentine et à la desmine dans la masse. Une tumeur myofibroblastique inflammatoire (IMT) a été définitivement diagnostiquée. Aucune récidive n’a été observée au cours d’une période de suivi de 43 mois. Bien que les IMT soient rares chez le chien, ils doivent être considérés comme un diagnostic différentiel des lésions de la vessie de type masse accompagnant un processus de maladie inflammatoire chronique.Message clinique clé:L’IMT canine doit être incluse dans les diagnostics différentiels des masses vésicales, en particulier lorsque les chiens présentent une irritation et une inflammation chroniques.(Traduit par Dr Serge Messier).

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Figures

FIGURE 1
FIGURE 1
An ultrasonogram (A) and a double-contrast cystogram (B) of a canine inflammatory myofibroblastic tumor. In (B), the arrowheads indicate bladder stones; the arrow indicates neck attachment of the pedunculated mass.
FIGURE 2
FIGURE 2
Surgical images of a canine inflammatory myofibroblastic tumor in the urinary bladder. A — Gross appearance of the intravesical mass. B — Excision of the mass including 5-millimeter mucosal margin. C — Intraluminal mucosal surface of the thickened cranioventral part of the bladder, showing multiple projections. D — Cross-section of the excised mass. The dotted line (B) indicates the excision line; the thin arrow (B) points to the neck attachment of the pedunculated mass; the thick arrows (B, D) highlight the bruised point assumed to be responsible for hematuria.
FIGURE 3
FIGURE 3
Microscopic images of a canine inflammatory myofibroblastic tumor in the urinary bladder. A mass in the submucosa contains an atypical spindle cell population and mixed cellular inflammation with hyperplasia of the overlying mucosa and Brunn’s nests (A, B; H&E staining). The immunoreactivity of the atypical spindle cell population is positive to vimentin (C) and desmin (D), but negative to smooth muscle actin (E) and faintly equivocal to calponin (F). Scale bars: A = 500 μm; B, C, D, E, F = 50 μm.
See this image and copyright information in PMC

References

    1. Meuten DJ, Meuten TLK. Tumors of the urinary system. In: Meuten DJ, editor. Tumors in Domestic Animals. 5th ed. Cary, North Carolina: Wiley Blackwell; 2017. pp. 632–688.
    1. Knapp DW, McMillan SK. Tumors of the urinary system. In: Withrow SJ, Vail DM, Page RL, editors. Withrow & MacEwen’s Small Animal Clinical Oncology. 5th ed. St. Louis, Missouri: Elsevier Saunders; 2013. pp. 572–582.
    1. Brunn H. Two interesting benign lung tumors of contradictory histopathology. J Thorac Surg. 1939;9:119–131.
    1. Golbert ZV, Pletnev SD. On pulmonary “pseudotumours”. Neoplasma. 1967;14:189–198. - PubMed
    1. Cerfolio RJ, Allen MS, Nascimento AG, et al. Inflammatory pseudotumors of the lung. Ann Thorac Surg. 1999;67:933–936. - PubMed

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