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Case Reports
. 2024 May 11:49:113-116.
doi: 10.1016/j.jdcr.2024.04.045. eCollection 2024 Jul.

Multifocal lymphangioendotheliomatosis with thrombocytopenia: Report of a case with favorable outcome into adulthood

Hasna Kerrouch  1   2 , Laurie Gouillon  1   3 , Remi Duclaux-Loras  3   4 , Carole Burillon  3   5 , Jean Kanitakis  1   3 , Naoufal Hjira  2 , Laurent Guibaud  3   6 , Denis Jullien  1   3
Affiliations
Case Reports

Multifocal lymphangioendotheliomatosis with thrombocytopenia: Report of a case with favorable outcome into adulthood

Hasna Kerrouch et al. JAAD Case Rep. .
No abstract available

Keywords: angiomatosis; multifocal lymphangioendotheliomatosis; thrombocytopenia.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Gastrointestinal endoscopy revealing multiple mucosal vascular lesions and bleeding throughout the stomach and colon.
Fig 2
Fig 2
Clinical features: widespread erythematous-violaceous macules with numerous firm nodules on the limbs, trunk, and lower extremities during childhood (A and B); diffuse erythematous-violaceous macules and erythematous-violaceous nodule on the anterior of the left leg in adulthood (C-E).
Fig 3
Fig 3
Histopathological examination shows a diffuse dermal-hypodermal vascular proliferation, made of dilated thin-walled vessels of variable size (A) and slightly hobnailed endothelial cells with intravascular papillary projections (B). Immunohistochemical staining reveals positivity of CD34 (C) and CD31 (D).
See this image and copyright information in PMC

References

    1. North P.E., Kahn T., Cordisco M.R., Dadras S.S., Detmar M., Frieden I.J. Multifocal lymphangioendotheliomatosis with thrombocytopenia. Arch Dermatol. 2004;140:599–606. - PubMed
    1. Prasad V., Fishman S.J., Mulliken J.B., et al. Cutaneovisceral angiomatosis with thrombocytopenia. Pediatr Dev Pathol. 2005;8:407–419. - PubMed
    1. Manor J., Patel K., Lacobas L., Margolin J.F., Mahajan P. Clinical variability in multifocal lymphangioendotheliomatosis with thrombocytopenia: a review of the literature. Pediat Hematol Oncol. 2021;38:367–377. - PubMed
    1. Lanoel A., Torres Huamani A.N., Feliu A., Sala M.J., Alvarez M., Cervini A.B. Multifocal lymphangioendotheliomatosis with thrombocytopenia: presentation of two cases treated with sirolimus. Pediatr Dermatol. 2016;33:e235–e239. - PubMed
    1. Khamaysi Z., Bergman R. Multifocal congenital lymphangioendotheliomatosis without gastrointestinal bleeding and/or thrombocytopenia. Am J Dermatopathol. 2010;32:804–808. - PubMed

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