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Review
. 2025 Apr:72 Suppl 2:e31155.
doi: 10.1002/pbc.31155. Epub 2024 Jul 2.

Surgical management of liver tumors

Kimberly J Riehle  1 , Sanjeev A Vasudevan  2 , Alexander Bondoc  3 , Alex G Cuenca  4 , Hanna Garnier  5 , Zachary Kastenberg  6 , Jonathan Roach  7 , Christopher B Weldon  4 , Jonathan Karpelowsky  8 , Tomoro Hishiki  9 , Gregory Tiao  3
Affiliations
Review

Surgical management of liver tumors

Kimberly J Riehle et al. Pediatr Blood Cancer. 2025 Apr.

Abstract

Two percent of pediatric malignancies arise primarily in the liver; roughly 60% of these cancers are hepatoblastoma (HB). Despite the rarity of these cases, international collaborative efforts have led to the consistent histological classification and staging systems, which facilitate ongoing clinical trials. Other primary liver malignancies seen in children include hepatocellular carcinoma (HCC) with or without underlying liver disease, fibrolamellar carcinoma (FLC), undifferentiated embryonal sarcoma of the liver (UESL), and hepatocellular neoplasm not otherwise specified (HCN-NOS). This review describes principles of surgical management of malignant pediatric primary liver tumors, within the context of comprehensive multidisciplinary care.

Keywords: hepatoblastoma; liver surgery; pediatric hepatocellular carcinoma.

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References

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