MMP9 and CCL18 associate with chronic urticaria while type I, IV, and VI collagens change with omalizumab treatment

Ewa A Bartko¹, Maiken Mellergaard^{2

3}, Solveig S Groen^{4

5}, Signe Holm Nielsen⁴, Jesper Elberling¹, Aase Handberg^{2

3}, Lars K Poulsen¹, Lars H Blom¹, Bettina M Jensen¹

Affiliations

¹ Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.
² Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
³ Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
⁴ ImmunoScience, Nordic Bioscience, Herlev, Denmark.
⁵ Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Ewa A Bartko et al. Allergy. 2024 Sep.

. 2024 Sep;79(9):2558-2561.

doi: 10.1111/all.16212. Epub 2024 Jul 2.

Ewa A Bartko¹, Maiken Mellergaard^{2

3}, Solveig S Groen^{4

5}, Signe Holm Nielsen⁴, Jesper Elberling¹, Aase Handberg^{2

3}, Lars K Poulsen¹, Lars H Blom¹, Bettina M Jensen¹

¹ Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.
² Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
³ Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
⁴ ImmunoScience, Nordic Bioscience, Herlev, Denmark.
⁵ Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

No abstract available

References

1. Saini S. Chronic spontaneous urticaria: etiology and pathogenesis. Immunol Allergy Clin N Am. 2014;34(1):33‐52. http://search.proquest.com/docview/1560105945/
1. Bartko EA, Elberling J, Blom LH, Poulsen LK, Jensen BM. Elevated, FcεRI‐dependent MRGPRX2 expression on basophils in chronic urticaria. Skin Health Dis. 2022;3:e195. doi:10.1002/ski2.195
1. Xie G, Yang H, Peng X, et al. Mast cell exosomes can suppress allergic reactions by binding to IgE. J Allergy Clin Immunol. 2018;141(2):788‐791. doi:10.1016/j.jaci.2017.07.040
1. Tedeschi A, Asero R, Lorini M, Marzano AV, Cugno M. Plasma levels of matrix metalloproteinase‐9 in chronic urticaria patients correlate with disease severity and C‐reactive protein but not with circulating histamine‐releasing factors. Clin Exp Allergy. 2010;40(6):875‐881. doi:10.1111/j.1365-2222.2010.03473.x
1. Bartko EA, Blom LH, Elberling J, Poulsen LK, Jensen BM. Expression of CCR8 and CCX‐CKR on basophils in chronic urticaria is amplified by IgE‐mediated activation. Biomedicine. 2023;11(6):1537. doi:10.3390/biomedicines11061537