Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)

doi:10.1007/s11657-024-01415-1

Multicenter Study

. 2024 Jul 2;19(1):55.

doi: 10.1007/s11657-024-01415-1.

Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)

Junichi Takada^{1

2}, Nobukazu Okimoto³, Manabu Tsukamoto⁴, Tomohiro Akatsuka⁵, Tsuneo Takebayashi⁶, Kousuke Iba⁷, Satoshi Ikeda⁸

Affiliations

¹ Osteoporosis Center, Sapporo Maruyama Orthopaedic Hospital, 1-3, N-7, W-27, Chuo-ku, Sapporo, 060-0007, Japan. osteoporosis-center@hokkaido.med.or.jp.
² Sapporo Kotoni Orthopaedic, Sapporo, Hokkaido, Japan. osteoporosis-center@hokkaido.med.or.jp.
³ Okimoto Clinic, Kure, Hiroshima, Japan.
⁴ Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
⁵ Sapporo Kotoni Orthopaedic, Sapporo, Hokkaido, Japan.
⁶ Osteoporosis Center, Sapporo Maruyama Orthopaedic Hospital, 1-3, N-7, W-27, Chuo-ku, Sapporo, 060-0007, Japan.
⁷ Department of Musculoskeletal Anti-aging Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan.
⁸ Department of Orthopaedic Surgery, Ken-Ai Memorial Hospital, Onga-gun, Fukuoka, Japan.

PMID: 38954145
DOI: 10.1007/s11657-024-01415-1

Multicenter Study

Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)

Junichi Takada et al. Arch Osteoporos. 2024.

. 2024 Jul 2;19(1):55.

doi: 10.1007/s11657-024-01415-1.

Authors

Junichi Takada^{1

2}, Nobukazu Okimoto³, Manabu Tsukamoto⁴, Tomohiro Akatsuka⁵, Tsuneo Takebayashi⁶, Kousuke Iba⁷, Satoshi Ikeda⁸

Affiliations

¹ Osteoporosis Center, Sapporo Maruyama Orthopaedic Hospital, 1-3, N-7, W-27, Chuo-ku, Sapporo, 060-0007, Japan. osteoporosis-center@hokkaido.med.or.jp.
² Sapporo Kotoni Orthopaedic, Sapporo, Hokkaido, Japan. osteoporosis-center@hokkaido.med.or.jp.
³ Okimoto Clinic, Kure, Hiroshima, Japan.
⁴ Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
⁵ Sapporo Kotoni Orthopaedic, Sapporo, Hokkaido, Japan.
⁶ Osteoporosis Center, Sapporo Maruyama Orthopaedic Hospital, 1-3, N-7, W-27, Chuo-ku, Sapporo, 060-0007, Japan.
⁷ Department of Musculoskeletal Anti-aging Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan.
⁸ Department of Orthopaedic Surgery, Ken-Ai Memorial Hospital, Onga-gun, Fukuoka, Japan.

PMID: 38954145
DOI: 10.1007/s11657-024-01415-1

Abstract

Trends toward more favorable improvement of the cortical bone parameters by once-weekly (56.5 μg once a week) and twice-weekly teriparatide (28.2 μg twice a week), and that of the trabecular bone parameters by once-daily (1/D) teriparatide (20 μg/day once a day) were shown.

Purpose: To examine the effects of differences in the amount of teriparatide (TPTD) per administration and its dosing frequency on the bone structure in the proximal femur by dual-energy X-ray absorptiometry (DXA)-based 3D-modeling (3D-SHAPER software).

Methods: This was a multicenter retrospective study. Patients aged 50 years or older with primary osteoporosis who continuously received once-/twice-weekly (1・2/W, n = 60) or 1/D TPTD (n = 14) administration for at least one year were included in the study. Measurement regions included the femoral neck (FN), trochanter (TR), femoral shaft (FS), and total proximal hip (TH). Concurrently, the bone mineral density (BMD) and Trabecular Bone Score (TBS) were measured.

Results: The cross-sectional area, cross-sectional moment of inertia, and section modulus in the FS were significantly improved in the 1・2/W TPTD group, as compared to the 1/D TPTD group. However, significant improvement of the cortical thickness and buckling ratio in the FN was observed in the 1/D TPTD group, as compared to the 1・2/W TPTD group. Trabecular BMD values in the FS and TH were significantly increased in the 1/D TPTD group, as compared to the 1・2/W TPTD group, while the cortical BMD values in the TR, FS, and TH were significantly increased in the 1・2/W TPTD group, as compared to the 1/D TPTD group.

Conclusion: Trends toward more favorable improvement of the cortical bone by 1・2/W TPTD and that of the trabecular bones by 1/D TPTD were observed.

Keywords: 3D-DXA; 3D-modeling; Bone strength; Bone structure; Teriparatide.

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References

1. Orimo H, Nakamura T, Hosoi T et al (2012) Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary. Arch Osteoporos 7:3–20. https://doi.org/10.1007/s11657-012-0109-9 - DOI - PubMed - PMC
1. Takusari E, Sakata K, Hashimoto T et al (2020) Trends in hip fracture incidence in Japan: estimates based on nationwide hip fracture surveys from 1992 to 2017. JBMR Plus 5:e10428. https://doi.org/10.1002/jbm4.10428 - DOI - PubMed - PMC
1. Saag KG, Petersen J, Brandi ML et al (2017) Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med 377:1417–1427. https://doi.org/10.1056/NEJMoa1708322 - DOI - PubMed
1. Al-Lamee R, Thompson D, Dehbi HM et al (2018) Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet 391:31–40. https://doi.org/10.1016/S0140-6736(17)32714-9 - DOI - PubMed
1. Hagino H, Sugimoto T, Tanaka S et al (2021) A randomized, controlled trial of 1/W teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05. Osteoporos Int 32:2301–2311. https://doi.org/10.1007/s00198-021-05996-2 - DOI - PubMed - PMC

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[1] Orimo H, Nakamura T, Hosoi T et al (2012) Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary. Arch Osteoporos 7:3–20. https://doi.org/10.1007/s11657-012-0109-9 - DOI - PubMed - PMC

[2] Orimo H, Nakamura T, Hosoi T et al (2012) Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary. Arch Osteoporos 7:3–20. https://doi.org/10.1007/s11657-012-0109-9 - DOI - PubMed - PMC

[3] Takusari E, Sakata K, Hashimoto T et al (2020) Trends in hip fracture incidence in Japan: estimates based on nationwide hip fracture surveys from 1992 to 2017. JBMR Plus 5:e10428. https://doi.org/10.1002/jbm4.10428 - DOI - PubMed - PMC

[4] Takusari E, Sakata K, Hashimoto T et al (2020) Trends in hip fracture incidence in Japan: estimates based on nationwide hip fracture surveys from 1992 to 2017. JBMR Plus 5:e10428. https://doi.org/10.1002/jbm4.10428 - DOI - PubMed - PMC

[5] Saag KG, Petersen J, Brandi ML et al (2017) Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med 377:1417–1427. https://doi.org/10.1056/NEJMoa1708322 - DOI - PubMed

[6] Saag KG, Petersen J, Brandi ML et al (2017) Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med 377:1417–1427. https://doi.org/10.1056/NEJMoa1708322 - DOI - PubMed

[7] Al-Lamee R, Thompson D, Dehbi HM et al (2018) Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet 391:31–40. https://doi.org/10.1016/S0140-6736(17)32714-9 - DOI - PubMed

[8] Al-Lamee R, Thompson D, Dehbi HM et al (2018) Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet 391:31–40. https://doi.org/10.1016/S0140-6736(17)32714-9 - DOI - PubMed

[9] Hagino H, Sugimoto T, Tanaka S et al (2021) A randomized, controlled trial of 1/W teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05. Osteoporos Int 32:2301–2311. https://doi.org/10.1007/s00198-021-05996-2 - DOI - PubMed - PMC

[10] Hagino H, Sugimoto T, Tanaka S et al (2021) A randomized, controlled trial of 1/W teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05. Osteoporos Int 32:2301–2311. https://doi.org/10.1007/s00198-021-05996-2 - DOI - PubMed - PMC

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Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)

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Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)

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