Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec;28(4):1457-1478.
doi: 10.1007/s10006-024-01277-4. Epub 2024 Jul 2.

Management and recurrence of the odontogenic keratocyst: an overview of systematic reviews

Thayanne Oliveira de Freitas Gonçalves  1 , Renata Matuck Roque Rangel  2 , Guido Artemio Marañón-Vásquez  2 , Larissa Soares-Silva  2 , Michelle Agostini  3 , Aline Corrêa Abrahão  3 , Mário José Romañach  3 , Lucianne Cople Maia  2
Affiliations
Review

Management and recurrence of the odontogenic keratocyst: an overview of systematic reviews

Thayanne Oliveira de Freitas Gonçalves et al. Oral Maxillofac Surg. 2024 Dec.

Abstract

Materials and methods: An extensive literature search among six eletronic databases and Grey Literature was used to identify systematic reviews (S) that could respond if: in individuals diagnosed with OKC (P), is there any influence of the treatment method (I/C) on the recurrence rate of the lesion (O)? After evaluating all titles and abstracts and then applying the eligibility criteria, the included studies were read in full, and data were extracted based on a standardized sheet ordered in the PICO sequence. The assessment of the quality of the systematic reviews included, was determined by AMSTAR2, and final synthesis were descriptively made based on the results and quality of the systematic reviews.

Results: From a total of 19 included systematic reviews, it was observed that the most used treatment for OKC was enucleation, followed by enucleation with adjuvant techniques and marsupialization. The mean percentage of recurrence was 16,2%, and the highest OKC recurrence rate was 43.2% after simple enucleation. The use of adjuvant techniques promoted reductions in OKC recurrence rates. The overall methodological quality of systematic reviews was critically low, and this parameter demonstrate the need for more studies to facilitate the choose of the treatment.

Conclusion: Despite being the most used treatment, simple enucleation is related to the highest rate of recurrence, except when performed after marsupialization/decompression. In addition, the use of adjuvant techniques has a strong impact on reducing the likelihood of recurrence. However, these findings are not conclusive because of the critically low quality of the systematic reviews.

Keywords: Odontogenic keratocyst; Recurrence rates; Surgery; Systematic review; Treatment.

PubMed Disclaimer

References

    1. Forteza-López A et al (2019) Tratamiento del tumor odontogénico queratoquístico: revisión sistemática. Rev Esp Cir Oral Maxilofac 41(1):26–32
    1. Dias G, Marques T, Coelho P (2016) Treatment options for keratocyst odontogenic tumour (KCOT): a systematic review. Oral Surg 1–17
    1. Wright JM, Li J-T Odontogenic keratocyst. In: WHO classification of tumours editorial board. Head and neck tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 2023–10–09]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https://tumourclassification.iarc.who.int/chaptercontent/52/126
    1. Al-Moraissi EA et al (2017) What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis. J Craniomaxillofac Surg 45:e131–e144 - DOI
    1. Johnson NR, Batstone MD, Savage NW (2012) Management and recurrence of keratocystic odontogenic tumor: a systematic review. Oral MaxillofacSurg e1-e6

LinkOut - more resources