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. 1985 Aug 16;229(4714):658-61.
doi: 10.1126/science.3895435.

Chromosome-sized DNA molecules of Plasmodium falciparum

L H Van der Ploeg, M Smits, T Ponnudurai, A Vermeulen, J H Meuwissen, G Langsley

Chromosome-sized DNA molecules of Plasmodium falciparum

L H Van der Ploeg et al. Science. .

Abstract

At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.

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