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. 2024 Nov;41(11):2979-2985.
doi: 10.1007/s10815-024-03175-w. Epub 2024 Jul 2.

The effects of age, mature oocyte number, and cycle number on cumulative live birth rates after planned oocyte cryopreservation

Sarah Druckenmiller Cascante  1 , James A Grifo  2 , Frederick Licciardi  2 , Carlos M Parra  2 , Amelia Kelly  2 , Alan S Berkeley  2
Affiliations

The effects of age, mature oocyte number, and cycle number on cumulative live birth rates after planned oocyte cryopreservation

Sarah Druckenmiller Cascante et al. J Assist Reprod Genet. 2024 Nov.

Abstract

Purpose: To examine the effects of age, mature oocyte number, and cycle number on cumulative live birth rates after planned oocyte cryopreservation (OC), with the goal of developing a patient counselling tool.

Methods: We performed a retrospective cohort study of all patients with ≥ 1 autologous oocyte thaw at our university-affiliated fertility center before 12/31/2023. Patients were included if they (1) had a live birth or ongoing pregnancy > 12 weeks from OC, or (2) used all oocytes and euploid/untested embryos from OC. Primary outcome was cumulative live birth / ongoing pregnancy rate (CLBR).

Results: 527 patients with 1 OC cycle, 149 patients with 2 OC cycles, and 55 patients with ≥ 3 OC cycles were included. Overall CLBR was 43%. CLBR was > 70% among patients who thawed ≥ 20 mature oocytes that were cryopreserved at age < 38 years. Multiple logistic regression showed that age at first OC and total number of mature oocytes thawed independently predicted CLBR, but number of OC cycles did not.

Conclusion: Patients must be counselled that younger age at OC and more mature oocytes improve CLBR. However, additional OC cycles do not independently improve CLBR. Our results can help patients decide whether to pursue additional OC cycles to obtain more oocytes.

Keywords: Assisted reproductive technology; Egg freezing; Egg thaw; Fertility preservation; Oocyte cryopreservation; Oocyte thaw.

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Conflict of interest statement

Declarations. Competing Interests: The authors have no competing interests to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Cumulative live birth / ongoing pregnancy rates (CLBRs) per patient based on age at first oocyte cryopreservation (OC)
Fig. 2
Fig. 2
Cumulative live birth / ongoing pregnancy rates (CLBRs) per patient based on total number of metaphase II oocytes (M2s) thawed
Fig. 3
Fig. 3
Multiple logistic regression model for cumulative live birth / ongoing pregnancy rate (CLBR) based on age at first cryopreservation and total number of metaphase II oocytes (M2s) thawed
See this image and copyright information in PMC

References

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