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. 2024 Sep;90(9):2092-2110.
doi: 10.1111/bcp.16153. Epub 2024 Jul 3.

Moderate and serious adverse reactions to antimicrobials among hospitalized children: A systematic review

Sheila Feitosa Ramos  1 , Letícia Gomes do Sacramento  1 , Rafaella Oliveira Santos de Silva  1 , Giulyane Targino Aires-Moreno  1 , Jonas Dos Santos Gomes  1 , Alessandra Rezende Mesquita  1 , Elisangela Costa Lima  2 , Divaldo Pereira de Lyra Jr  1
Affiliations
Free article

Moderate and serious adverse reactions to antimicrobials among hospitalized children: A systematic review

Sheila Feitosa Ramos et al. Br J Clin Pharmacol. 2024 Sep.
Free article

Abstract

Aims: This systematic review aimed to investigate the occurrence of moderate and severe adverse drug reactions (ADRs) to antimicrobials among hospitalized children.

Methods: The PubMed/Medline, Cochrane Library, Embase, Web of Science, Scopus, Lilacs and CINAHL databases were searched in April 2023 to systematically review the published data describing the characteristics of moderate and severe ADRs to antimicrobials among hospitalized children. The search was carried out without date restrictions, up to the search date (April, 2023).

Results: At the end of the selection process, 30 articles met the inclusion criteria. Cutaneous reactions were the primary serious clinical manifestations in most articles (19/30), followed by erythema multiforme (71 cases), Stevens-Johnson syndrome (72 cases), and toxic epidermal necrolysis (22 cases). The main antimicrobials involved in moderate and severe ADRs were penicillins, cephalosporins and sulfonamides. Regarding the primary outcomes, 30% (9/30) of the articles reported deaths, and 46.7% (14/30) of studies reported increased lengths of hospital stay, need for intensive care, and transfer to another hospital. Regarding the main interventions, 10% (3/30) of the articles mentioned greater monitoring, suspension, medication substitution or prescription of specific medications for the symptomatology.

Conclusions: The findings of this review could be used to identify areas for improvement and help health professionals and policymakers develop strategies. In addition, we emphasize the importance of knowing about ADRs so that there is adequate management to avoid undesirable consequences.

Keywords: adverse drug reactions; antimicrobials; children; severity; systematic review.

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