Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct;48(7):787-792.
doi: 10.1002/jpen.2668. Epub 2024 Jul 3.

Urine sodium concentration and 28-day weight velocity in preterm infants: A retrospective cohort study

Natalia Brody  1 , Chelsea Oakes  1 , Hanwen Huang  2 , Brian K Stansfield  1
Affiliations

Urine sodium concentration and 28-day weight velocity in preterm infants: A retrospective cohort study

Natalia Brody et al. JPEN J Parenter Enteral Nutr. 2024 Oct.

Abstract

Background: Urine sodium concentration has been suggested as a marker to guide enteral sodium supplementation in preterm infants; however, no previous data have demonstrated relationships between urine sodium concentration and postnatal growth.

Methods: We performed a single-center retrospective cohort study on 224 preterm infants admitted to the neonatal intensive care unit at the Children's Hospital of Georgia between January 2010 and July 2022. Spot urine sodium was measured in preterm infants (<34 weeks postmenstrual age [PMA]) between days of life (DOLs) 7 and 28. Our exposure of interest was spot urine sodium concentration (milliequivalents per liter) obtained between postnatal days 7 and 28, and our primary outcome was weight velocity (grams per kilograms per day) determined at DOL 28. Statistical relationships were assessed by multivariate analysis with subgroup comparisons by Student t test and analysis of variance.

Results: In 224 preterm infants (199 ± 17 days, 56% male, 71% Black), urine sodium concentration did not associate with weight velocity at DOL 28 and 36 weeks PMA. Urine sodium concentration was weakly associated with gestational age at birth, and Black preterm infants had higher urine sodium values when compared with "other," but not White preterm infants.

Conclusion: Spot urine sodium during the first month of life does not associate with weight velocity at DOL 28 or 36 weeks PMA.

Keywords: critical care; enteral nutrition; fluids‐electrolytes/acid‐base; neonates; nutrition assessment.

PubMed Disclaimer

References

REFERENCES

    1. Embleton ND, Moltu SJ, Lapillonne A, et al. Enteral nutrition in preterm infants (2022): a position paper from the ESPGHAN Committee on Nutrition and Invited Experts. J Pediatr Gastroenterol Nutr. 2023;76(2):248‐268. doi:10.1097/MPG.0000000000003642
    1. Koletzko B, Cheah F‐CL, Domellöf M, et al. Scientific basis and practical application of nutritional care for preterm infants. World Rev Nutr Diet. 2021;122 XIII‐XIV. doi:10.1159/000514773
    1. Perrin MT, Friend LL, Sisk PM. Fortified donor human milk frequently does not meet sodium recommendations for the preterm infant. J Pediatr. 2022;244:219‐223. doi:10.1016/j.jpeds.2022.01.029
    1. Gates A, Hair AB, Salas AA, Thompson AB, Stansfield BK. Nutrient composition of donor human milk and comparisons to preterm human milk. J Nutr. 2023;153(9):2622‐2630. doi:10.1016/j.tjnut.2023.07.012
    1. Gates A, Marin T, De Leo G, Waller JL, Stansfield BK. Nutrient composition of preterm mother's milk and factors that influence nutrient content. Am J Clin Nutr. 2021;114(5):1719‐1728. doi:10.1093/ajcn/nqab226

Publication types

LinkOut - more resources