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. 2024 Oct;14(10):1647-1651.
doi: 10.1002/alr.23401. Epub 2024 Jul 3.

The role of revision sinus surgery in the initiation of dupilumab therapy: A real-world study of molecular and cellular features

Abigail Gaffar  1 , Abdul Rahman Alenezi  1 , Kathleen M Kelly  2 , Heather M Kulaga  1 , Hsin-Tzu Keng  1 , Amy Smith  1 , Andrew P Lane  1
Affiliations

The role of revision sinus surgery in the initiation of dupilumab therapy: A real-world study of molecular and cellular features

Abigail Gaffar et al. Int Forum Allergy Rhinol. 2024 Oct.

Abstract

A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab. Revision sinus surgery immediately prior to dupilumab reduces long-term interleukin (IL)-4/IL-13 tissue mRNA. Pre-dupilumab revision surgery is associated with reduced tissue eosinophils and GATA-3+ cells.

Keywords: IL‐13; IL‐4; chronic rhinosinusitis with nasal polyposis; dupilumab; sinus surgery.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

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