Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jul 1;28(7):354-356.
doi: 10.5588/ijtld.23.0494.

Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

M Yohane  1 , F Naufal  2 , A Mendoza-Ticona  3 , E M Svensson  4 , I R Weir  5 , K K Scarsi  6 , D W Haas  7 , G Maartens  8 , J Metcalfe  2
Affiliations
Case Reports

Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

M Yohane et al. Int J Tuberc Lung Dis. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: JM, DH, ES, KS, IW, and GM have institutional funding from NIH. JM is also chair of the NIH ACTG Trial A5362. ES has institutional funding from UNITE4TB, a Veni Grant from the Dutch Research Council (The Hague, Utrecht, The Netherlands), and a UNITAID grant. ES has research collaborations with TB Alliance (New York, NY, USA) and Janssen Pharmaceuticals (Beerse, Belgium). ES is a DSMB member for the BE-PEOPLE Study and a member of the CHEETA Task Force. The remaining authors do not have any conflicts of interest.

Figures

Figure.
Figure.
Timeline of events. The accidental overdose of study medications occurred on Day 2 (two doses of study treatments), followed by a rapid rise primarily in conjugated bilirubin and subsequent quick resolution in liver biochemistry levels: total bilirubin (peak, 4.1 mg/dL), conjugated bilirubin (peak: 2.45 mg/dL), ALT (peak: 187 IU/L), AST (peak: 64 IU/L), and ALP (peak: 187 IU/L) are shown as multiples of their respective ULN range. ALT = alanine transaminase; AST = aspartate transaminase; ALP = alkaline phosphatase; IU = international units.
See this image and copyright information in PMC

References

    1. Metcalfe J. Clofazimine- and rifapentine-containing treatment shortening regimens in drug-susceptible tuberculosis: The CLO-FAST Study. ClinicalTrials.gov, 2020. NCT04311502. https://clinicaltrials.gov/ct2/show/NCT04311502 Accessed December 2022.
    1. Guglielmetti L, et al. Rifapentine access in Europe: growing concerns over key tuberculosis treatment component. Eur Respir J 2022;59(5):2200388. - PMC - PubMed
    1. Frick M. An activist’s guide to rifapentine for the treatment of TB infection. Treatment Action Group, 2020. https://www.treatmentactiongroup.org/publication/an-activists-guide-to-r... Accessed January 2023.
    1. Chung JY, et al. Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers. Clin Pharmacol Ther 2005;78(4):342–350. - PubMed
    1. Savic RM, et al. Population pharmacokinetics of rifapentine and desacetyl rifapentine in healthy volunteers: Nonlinearities in clearance and bioavailability. Antimicrob Agents Chemother 2014;58(6):3035–3042. - PMC - PubMed

LinkOut - more resources