[Possibilities of using monoclonal antibodies to CEA in scintigraphic diagnosis of tumors]

Abstract

Improved tumour localization by scintigraphy is the aim of application of radiolabelled antibodies in nuclear medical tumour diagnostics. Results from the literature until 1984 in the field of monoclonal antibodies (Mabs) against CEA are discussed in the following points: type and stability of the radiolabelling; accumulation and biologic activity of Mabs in the animal; distribution of Mabs in clinical application and possible injury for the patient; methods for increased accumulation in the tumor and improved tumour-imaging. Further work is needed in this field before introducing this method into the diagnostic routine.