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. 2024 Apr 30;13(3):301-305.
doi: 10.1007/s13691-024-00682-6. eCollection 2024 Jul.

A case of dedifferentiated liposarcoma discovered due to an intrascrotal calcified ossification

Haruna Arai  1   2 , Hirofumi Sogabe  1 , Shinnosuke Morikawa  3 , Osuke Arai  2 , Ryuta Watanabe  2 , Akira Ozawa  1 , Akira I Hida  3 , Tokuhiro Iseda  1 , Kenichi Kohashi  4 , Yoshinao Oda  5
Affiliations

A case of dedifferentiated liposarcoma discovered due to an intrascrotal calcified ossification

Haruna Arai et al. Int Cancer Conf J. .

Abstract

Dedifferentiated liposarcoma is a rare cancer with a poor prognosis. A 52-year-old man presented with a chief complaint of a mass in his left scrotum. He came with suspected testicular tumor, but all the measured tumor markers were negative. Imaging test showed approximately 2 cm diameter mass accompanied by calcification with some substantial components between the testis and epididymis. Left high testicular resection was performed. The tumor had no continuity between the testis and epididymis, and the spermatic cord transection was negative. Pathological findings showed well differentiated fatty component and a dedifferentiated component around the trabecular bone-like tissue. We observed dedifferentiated dysmorphic cells mixed with fatty droplets of unequal size. Immunostaining led to the diagnosis of dedifferentiated liposarcoma. No additional postoperative therapy was performed. The possibility of dedifferentiated liposarcoma should be kept in mind even if mass is confined to the scrotum and consisted of calcification. In the case of an intrascrotal calcified mass with malignant perspective, radical surgery is highly recommended.

Keywords: Calcification; Dedifferentiated liposarcoma; Scrotum.

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Conflict of interest statement

Conflict of interestThe authors declare that have no conflict of interest.

Figures

Fig. 1
Fig. 1
(A) CT (axial) It reveals an inguinal mass (white arrow), which mainly consisted of calcification. There is no metastasis. (B) MRI (T2-weighted coronal image with fat suppression). It reveals the tumor consisting of few solid ingredients. (C) MRI (T2-weighted horizontal image with fat suppression). It shows no fat signal area on the tumor
Fig. 2
Fig. 2
Extracted specimen, before formalin fixation. Tumor (yellow arrow) reveals between testis and epididymis
Fig. 3
Fig. 3
(A) HE stains × 4: Well differentiated fat components (blue arrow) and dedifferentiated components (red arrow) are observed around the spongy bone-like tissue (yellow arrow). (B) HE stains × 100: Atypical cells mixed in adipose tissue (red arrow). (C) MDM2 stains × 400: The tumor cells are partially positive for MDM2. (D) p16 stains × 400: The tumor cells are diffusely positive for p16
See this image and copyright information in PMC

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