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Review
. 2024 Jun 17:16:1417989.
doi: 10.3389/fnagi.2024.1417989. eCollection 2024.

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

Yun Liu  1 , Dan Feng  1 , Ling Shui  2 , Yu-Jie Wang  1 , Li Yu  1 , Yu-Qi Liu  1 , Jin-Yong Tian  2
Affiliations
Review

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

Yun Liu et al. Front Aging Neurosci. .

Abstract

Background: Ferroptosis, a newly proposed concept of programmed cell death, has garnered significant attention in research across different diseases in the last decade. Despite thorough citation analyses in neuroscience, there is a scarcity of information on ferroptosis research specifically related to neurodegenerative diseases.

Method: The Web of Science Core Collection database retrieved relevant articles and reviews. Data on publications, countries, institutions, authors, journals, citations, and keywords in the included studies were systematically analyzed using Microsoft Excel 2019 and CiteSpace 6.2.R7 software.

Result: A comprehensive analysis and visualization of 563 research papers on ferroptosis in neurodegenerative diseases from 2014 to 2023 revealed emerging research hotspots and trends. The number of annual publications in this field of study has displayed a pattern of stabilization in the early years of the decade, followed by a notable increase in the later years and peaking in 2023 with 196 publications. Regarding publication volume and total citations, notable research contributions were observed from countries, institutions, and authors in North America, Western Europe, and China. Current research endeavors primarily focus on understanding the intervention mechanisms of neurodegenerative diseases through the ferroptosis pathway and exploring and identifying potential therapeutic targets.

Conclusion: The study highlights key areas of interest and emerging trends in ferroptosis research on neurodegenerative diseases, offering valuable insights for further exploration and potential directions for diagnosing and treating such conditions.

Keywords: CiteSpace; bibliometric analysis; ferroptosis; hotspots; knowledge graph; neurodegenerative diseases.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Core mechanisms of ferroptosis.
Figure 2
Figure 2
Number of publications and the model fitting curve of total annual publications.
Figure 3
Figure 3
Top 15 journals of ferroptosis in ND research ranked by publication number.
Figure 4
Figure 4
CiteSpace network visualization map of country/regions involved in ferroptosis of ND research.
Figure 5
Figure 5
CiteSpace network visualization map of institutions involved in ferroptosis of ND research.
Figure 6
Figure 6
CiteSpace network visualization map of co-cited references involved in ferroptosis of ND research.
Figure 7
Figure 7
CiteSpace network visualization map of keywords clusters analysis involved in ferroptosis of ND research.
Figure 8
Figure 8
Keywords citation bursts analysis of related literature. The red line shows the time frame during which the keyword bursts were discovered, while the blue line shows the time interval.
See this image and copyright information in PMC

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