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Review
. 2024 Jun 19:11:1372434.
doi: 10.3389/fmed.2024.1372434. eCollection 2024.

Research advances in serum chitinase-3-like protein 1 in liver fibrosis

Xingwei Hu  1   2 , Wenhan Liu  1   2 , Jianhua Liu  1   2 , Bojian Wang  1   2 , Xiaosong Qin  1   2
Affiliations
Review

Research advances in serum chitinase-3-like protein 1 in liver fibrosis

Xingwei Hu et al. Front Med (Lausanne). .

Abstract

While liver fibrosis remains a serious, progressive, chronic liver disease, and factors causing damage persist, liver fibrosis may develop into cirrhosis and liver cancer. However, short-term liver fibrosis is reversible. Therefore, an early diagnosis of liver fibrosis in the reversible transition phase is important for effective treatment of liver diseases. Chitinase-3-like protein 1 (CHI3L1), an inflammatory response factor that participates in various biological processes and is abundant in liver tissue, holds promise as a potential biomarker for liver diseases. Here, we aimed to review research developments regarding serum CHI3L1 in relation to the pathophysiology and diagnosis of liver fibrosis of various etiologies, providing a reference for the diagnosis, treatment, and prognosis of liver diseases.

Keywords: biomarker; chitinase-3-like protein 1; liver fibrosis; non-alcoholic fatty liver disease; viral hepatitis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Biological functions of CHI3L1.
See this image and copyright information in PMC

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