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. 2024 Jul 4;15(1):262.
doi: 10.1007/s12672-024-01143-5.

Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases

Jie Liu #  1   2 , Zhi-Han Zhong #  2 , Shu-Sen Zheng  3
Affiliations

Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases

Jie Liu et al. Discov Oncol. .

Abstract

Background: Lymphangioma is a rare cystic tumor that occurs across different locations. Retroperitoneal lymphangioma accounts for about 1% of all lymphangiomas. In this study, we report the clinicopathological features of retroperitoneal lymphangioma and describe our experience in treating this disease.

Methods: We collected clinical data from all patients who were pathologically diagnosed with retroperitoneal lymphangioma at Zhejiang Provincial People's Hospital, between June 2013 and August 2022.

Results: The 7 and 8 male and female patients analyzed herein had a mean age of 48.6 (SD 14.24) years at diagnosis. The mean duration of follow-up was 4.7 years. Among them, 66.67% were asymptomatic, with the rest manifesting abdominal pain, nausea, low back pain and elevated blood pressure as the main symptoms. Preoperative diagnosis and evaluation of cysts were mainly performed via computed tomography (CT) (n = 10, 66.67%) or magnetic resonance imaging (MRI) (n = 8, 53.33%). All patients were completely resected following surgery. Immunohistochemical analysis, performed on 6 patients, revealed that they were positive for D2-40. A total of 4, 4 and 3 patients were positive for CD31, CD34 and SMA, respectively. Moreover, the study cohort had an average postoperative hospital stay of 6.6 days. Follow up, after the end of the study, revealed no relapse in any of the 15 patients.

Conclusions: Lymphangioma is a benign tumor of the lymphatic system. Although typical imaging features can be accurate for preoperative diagnosis, histological examination is crucial to final confirmation. Complete surgical resection is the best option to limit the risk of recurrence in cases with symptomatic lesions.

Keywords: CD34; D2-40; Diagnostic; Prognosis; Retroperitoneal lymphangioma.

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Conflict of interest statement

No competing interests.

Figures

Fig. 1
Fig. 1
Figure a shows Enhanced CT images of retroperitoneal lymphangioma; Figure b shows CT scan without contrast
Fig. 2
Fig. 2
Retroperitoneal cystic lymphangioma with white emulsion leakage during operation
Fig. 3
Fig. 3
Enhanced MRI image of retroperitoneal lymphangioma
Fig. 4
Fig. 4
HE piceure of four cases of retroperitoneal lymphangioma. (All pictures have 10x10 magnification)
Fig. 5
Fig. 5
Four cases of retroperitoneal lymphangioma were D2-40 positive (All pictures have 10x10 magnification)
Fig. 6
Fig. 6
Figure a shows CD34 positive; Figure b shows CD31 positive; Figure c and d shows SMA positive. (All pictures have 10x10 magnification)
See this image and copyright information in PMC

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References

    1. Zhou Q, Zheng JW, Mai HM, Luo QF, Fan XD, Su LX, et al. Treatment guidelines of lymphatic malformations of the head and neck. Oral Oncol. 2011;47:1105–1109. doi: 10.1016/j.oraloncology.2011.08.001. - DOI - PubMed
    1. Mansour S, Kluger Y, Khuri S. Adult primary retroperitoneal lymphangioma: updated facts. World J Oncol. 2023;14(1):15–20. doi: 10.14740/wjon1561. - DOI - PMC - PubMed
    1. Suhani S, Aggarwal L, Ali S, Thomas S. Giant retroperitoneal lymphangioma: a rare entity. Indian J Surg. 2014;76(5):402–4. doi: 10.1007/s12262-013-0989-y. - DOI - PMC - PubMed
    1. Xiao J, Shao Y, Zhu S, He X. Characteristics of adult abdominal cystic lymphangioma: a single-center Chinese cohort of 12 cases. BMC Gastroenterol. 2020;20(1):244. doi: 10.1186/s12876-020-01388-8. - DOI - PMC - PubMed
    1. Surlin V, Georgescu E, Dumitrescu C, Râmboiu S, Comănescu MV, Ghiluşi M. Retropancreatic cystic lymphangioma—considerations upon a case. Rom J Morphol Embryol. 2011;52(Suppl):493–496. - PubMed

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