Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024:104:383-408.
doi: 10.1007/978-3-031-58843-3_14.

Structures and Electron Transport Paths in the Four Families of Flavin-Based Electron Bifurcation Enzymes

Xiang Feng  1 , Gerrit J Schut  2 , Michael W W Adams  2 , Huilin Li  3
Affiliations
Review

Structures and Electron Transport Paths in the Four Families of Flavin-Based Electron Bifurcation Enzymes

Xiang Feng et al. Subcell Biochem. 2024.

Abstract

Oxidoreductases facilitating electron transfer between molecules are pivotal in metabolic pathways. Flavin-based electron bifurcation (FBEB), a recently discovered energy coupling mechanism in oxidoreductases, enables the reversible division of electron pairs into two acceptors, bridging exergonic and otherwise unfeasible endergonic reactions. This chapter explores the four distinct FBEB complex families and highlights a decade of structural insights into FBEB complexes. In this chapter, we discuss the architecture, electron transfer routes, and conformational changes across all FBEB families, revealing the structural foundation that facilitate these remarkable functions.

Keywords: Catalytic mechanism; Electron bifurcation; Electron transfer; Flavin; Iron-sulfur cluster; Structural biology; cryoEM.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Appel L, Willistein M, Dahl C, Ermler U, Boll M (2021) Functional diversity of prokaryotic HdrA(BC) modules: role in flavin-based electron bifurcation processes and beyond. Biochim Biophys Acta Bioenerg 1862(4):148379. https://doi.org/10.1016/j.bbabio.2021.148379 - DOI - PubMed
    1. Baum H, Rieske JS, Silman HI, Lipton SH (1967) On the mechanism of electron transfer in complex iii of the electron transfer chain. Proc Natl Acad Sci U S A 57(3):798–805. https://doi.org/10.1073/pnas.57.3.798 - DOI - PubMed - PMC
    1. Baymann F, Schoepp-Cothenet B, Duval S, Guiral M, Brugna M, Baffert C, Russell MJ, Nitschke W (2018) On the natural history of flavin-based electron bifurcation. Front Microbiol 9:1357. https://doi.org/10.3389/fmicb.2018.01357 - DOI - PubMed - PMC
    1. Berrisford JM, Sazanov LA (2009) Structural basis for the mechanism of respiratory complex I. J Biol Chem 284(43):29773–29783. https://doi.org/10.1074/jbc.M109.032144 - DOI - PubMed - PMC
    1. Buckel W, Thauer RK (2018a) Flavin-based electron bifurcation, a new mechanism of biological energy coupling. Chem Rev 118(7):3862–3886. https://doi.org/10.1021/acs.chemrev.7b00707 - DOI - PubMed

LinkOut - more resources