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Editorial
. 2024 Sep 9;47(9):zsae151.
doi: 10.1093/sleep/zsae151.

Rhythms in cortisol mediate sleep and circadian impacts on health

Peter Y Liu  1
Affiliations
Editorial

Rhythms in cortisol mediate sleep and circadian impacts on health

Peter Y Liu. Sleep. .
No abstract available

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Figures

Figure 1.
Figure 1.
Conceptual framework for the disruption of the circadian regulation of clocks in peripheral organs by conflicting signaling from the central circadian clock and behavioral cycles (feeding–fasting, sleep–wake, and activity–rest). The central timing signal is cortisol for Leydig cells in the testes, and peripheral organs responsible for whole-body metabolism (gut, pancreas, muscle, fat, and liver), whereas peripheral signals governed by behavior include glucagon, insulin, other hormones, metabolites, and others. When peripheral clocks receive conflicting signals, clocks are disrupted and desynchrony occurs, which leads to insulin resistance and other pathologies.
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