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Comment
. 2024 Jul 5;385(6704):27-28.
doi: 10.1126/science.adq3757. Epub 2024 Jul 4.

Developing a pill to treat sickle cell disease

Douglas Higgs  1 , Mira Kassouf  1
Affiliations
Comment

Developing a pill to treat sickle cell disease

Douglas Higgs et al. Science. .

Abstract

A newly identified epigenetic modifier increases fetal hemoglobin in preclinical studies.

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Comment on

  • A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
    Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F, Belew MS, Mao X, Wang J, Chitnis S, Niu W, Hachey A, Cobb JS, Savage NA, Burke A, Paulk J, Dovala D, Lin J, Clifton MC, Ornelas E, Ma X, Ware NF, Sanchez CC, Taraszka J, Terranova R, Knehr J, Altorfer M, Barnes SW, Beckwith REJ, Solomon JM, Dales NA, Patterson AW, Wagner J, Bouwmeester T, Dranoff G, Stevenson SC, Bradner JE. Ting PY, et al. Science. 2024 Jul 5;385(6704):91-99. doi: 10.1126/science.adk6129. Epub 2024 Jul 4. Science. 2024. PMID: 38963839

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