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. 2024 Jun 19:15:1399062.
doi: 10.3389/fpsyt.2024.1399062. eCollection 2024.

Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder

Kenta Kato  1 , Hirofumi Tomiyama  1 , Keitaro Murayama  2 , Taro Mizobe  1 , Akira Matsuo  1 , Nami Nishida  1 , Kou Matukuma  1 , Mingi Kang  3 , Kenta Sashikata  3 , Kazufumi Kikuchi  4 , Osamu Togao  4 , Tomohiro Nakao  1
Affiliations

Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder

Kenta Kato et al. Front Psychiatry. .

Abstract

Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear.

Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels.

Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms.

Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

Keywords: cognitive control; functional connectivity; hoarding disorder; resting-state; seed-based analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Results of seed-based analysis comparing right insula-right IFG and right insula-left STG connectivity between individuals with HD and HCs. (A) Patients with HD showed significantly lower functional connectivity from the right insula to the right IFG and left STG compared to HCs (cluster size corrected significance p < 0.05, after applying a per-voxel height threshold of p < 0.001). Peak coordinates are given in MNI space. (B) Group difference in right insula-right IFG connectivity; compared to HCs, individuals with HD exhibit significantly lower connectivity between right insula and right IFG. (C) Group difference in right insula-left STG connectivity; compared to HCs, individuals with HD exhibit significantly lower connectivity between right insula and left STG. HC, healthy control; HD, hoarding disorder; IFG, inferior frontal gyrus; MNI, Montreal Neurological Institute; ROI, region of interest; STG, superior temporal gyrus. *p-FDR <.05 (representing a Holm-corrected p-value adjusted for three ROIs comparisons after cluster-level FDR correction).
See this image and copyright information in PMC

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