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Review
. 2024 Jun 4;16(6):e61658.
doi: 10.7759/cureus.61658. eCollection 2024 Jun.

Clinical Performance of Implant-Supported Prostheses in the Rehabilitation of Patients Previously Treated for Medication-Related Osteonecrosis of the Jaws (MRONJ): A Systematic Review

Eduardo Anitua  1 , Mohammad Alkhraisat  2 , Asier Eguia  3
Affiliations
Review

Clinical Performance of Implant-Supported Prostheses in the Rehabilitation of Patients Previously Treated for Medication-Related Osteonecrosis of the Jaws (MRONJ): A Systematic Review

Eduardo Anitua et al. Cureus. .

Abstract

There is a lack of consensus on managing resultant bone and soft tissue defects or on restoring oral function and aesthetics following medication-related osteonecrosis of the jaws (MRONJ) lesion healing. This clinical challenge presents a dilemma for practitioners. Removable prostheses pose a recurrence risk if poorly fitted and may inadequately restore function or aesthetics in cases of significant bone defect. Dental implant-supported prostheses could enhance function and quality of life, though their risks and indications are not well-defined. This systematic review examines the clinical outcomes and complications associated with implant-supported rehabilitations post-MRONJ surgery. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations and it was pre-registered in the Prospective Register of Systematic Reviews (PROSPERO) (CRD42023492539).

Keywords: dental implants; dental prosthesis; implant-supported prosthesis; medication-related osteonecrosis of the jaw; systematic review.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: Eduardo Anitua Mohammad Hamdan Alkhraisat declare(s) employment from BTI Biotechnology Institute. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Study selection workflow
Study selection workflow diagram following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
See this image and copyright information in PMC

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