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Review
. 2024 Oct;44(10):2517-2537.
doi: 10.1111/liv.15948. Epub 2024 Jul 5.

Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (AFEF)

Cindy Neuzillet  1 , Marie Decraecker  2 , Hélène Larrue  3 , Line C Ntanda-Nwandji  4 , Louise Barbier  5 , Sandrine Barge  6 , Arthur Belle  7 , Carine Chagneau  8 , Julien Edeline  9 , Catherine Guettier  10 , Florence Huguet  11 , Jérémie Jacques  12 , Brigitte Le Bail  13 , Sarah Leblanc  14 , Maïté Lewin  15 , David Malka  16 , Maxime Ronot  17 , Véronique Vendrely  18 , Éric Vibert  19 , Christophe Bureau  3 , Marc Bourliere  20 , Nathalie Ganne-Carrie  21 , Jean-Frédéric Blanc  2
Affiliations
Review

Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (AFEF)

Cindy Neuzillet et al. Liver Int. 2024 Oct.

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant primary liver cancer. iCCA may develop on an underlying chronic liver disease and its incidence is growing in relation with the epidemics of obesity and metabolic diseases. In contrast, perihilar cholangiocarcinoma (pCCA) may follow a history of chronic inflammatory diseases of the biliary tract. The initial management of CCAs is often complex and requires multidisciplinary expertise. The French Association for the Study of the Liver wished to organize guidelines in order to summarize the best evidence available about several key points in iCCA and pCCA. These guidelines have been elaborated based on the level of evidence available in the literature and each recommendation has been analysed, discussed and voted by the panel of experts. They describe the epidemiology of CCA as well as how patients with iCCA or pCCA should be managed from diagnosis to treatment. The most recent developments of personalized medicine and use of targeted therapies are also highlighted.

Keywords: cytology; guidelines; interventional radiology; intrahepatic cholangiocarcinoma; pathology; perihilar cholangiocarcinoma; risk factor; screening; stenting; surgery; targeted therapies.

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References

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