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. 2024;20(10):555-561.
doi: 10.1080/14796678.2024.2365552. Epub 2024 Jul 5.

Relationship between angiogenesis biomarker endocan and apolipoproteins in patients with acute myocardial infarction

Mehdi Hassanpour  1   2 , Reza Rahbarghazi  3   4 , Aysa Rezabakhsh  5 , Rasa Khodavirdilou  6 , Akbar Darbin  1 , Elmira Zolali  7 , Nasser Safaei  8
Affiliations

Relationship between angiogenesis biomarker endocan and apolipoproteins in patients with acute myocardial infarction

Mehdi Hassanpour et al. Future Cardiol. 2024.

Abstract

Aim: In the current study, serum levels of endocan in patients attended with ST-elevation myocardial infarction, as well as the possible correlation with apolipoprotein-A1 (APO-A1) and APO-B were investigated.Materials & methods: In 80 men, endocan, cTnI, APO-A1, and APO-B levels were measured. Finally, the correlation of endocan with APO-A1, APO-B, and APO-B/ APO-A1 ratio was assessed.Results: Significant changes in APO-A1, APO-B, endocan levels, and APO-B/APO-A1 ratio were found in acute myocardial infarction cases compared with the control arm (p < 0.05). In addition, our finding showed a significant correlation between APO-B and endocan levels, but not APO-A.Conclusion: High endocan level is an independent indicator of endothelial dysfunction and ischemic cardiovascular conditions, which could be related to APO-B.

Keywords: ST-elevation myocardial infarction; acute myocardial infarction; angiogenesis; apolipoproteins; endocan; reliable indicator.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
The serum levels of endocan, APO-A1, and APO-B. As shown in this figure, the levels of APO-B, endocan, and cTnI are significantly higher in AMI patients compared with healthy subjects. However, serum levels of APO-A1 are lowered in AMI conditions. AMI: Acute myocardial infarction; APO-A and -B: Apolipoprotein A and -B; cTnI: Cardiac troponin I; Endo: Endocan.
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