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Case Reports
. 2024 Nov-Dec;41(6):1134-1140.
doi: 10.1111/pde.15672. Epub 2024 Jul 5.

Spontaneous multifocal pyogenic granulomas

Lindsey J Gaghan  1 , Isaac T Sluder  2 , Ashwath Sampath  3 , Jeyhan Wood  4 , Jennifer Brondon  5 , Julie Blatt  5 , Jayson Miedema  3   6 , Elizabeth Nieman  3
Affiliations
Case Reports

Spontaneous multifocal pyogenic granulomas

Lindsey J Gaghan et al. Pediatr Dermatol. 2024 Nov-Dec.

Abstract

Cutaneous pyogenic granulomas (PGs) are common, benign vascular tumors of uncertain pathogenesis; however, a growing body of literature suggests that the formation of PGs may be secondary to genetic alterations in both the Ras/Raf/MAPK and PI3K/Akt/mTOR pathways. We present three cases of spontaneous multifocal PGs that first presented in infancy, were not associated with other vascular anomalies or discernable etiology, harbored somatic genetic variants in the Ras/Raf/MAPK pathway (NRAS n = 2, FGFR1 n = 1), were refractory to treatment with beta-blockers and mTOR inhibitors, and responded best to pulsed dye laser. We propose the term "spontaneous multifocal PGs" to describe this entity.

Keywords: FGFR1; NRAS; RAS; Ras/Raf/MAPK; lobular capillary hemangioma; pulsed dye laser; pyogenic granuloma; somatic overgrowth mutation.

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References

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