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Editorial
. 2024;13(2):115-118.
doi: 10.3233/JHD-240043.

Refining the Language of Huntington's Disease Progression with the Huntington's Disease Integrated Staging System (HD-ISS)

Cristina Sampaio  1   2 , Sandra K Kostyk  3   4 , Sarah J Tabrizi  5   6 , Anne E Rosser  7   8
Affiliations
Editorial

Refining the Language of Huntington's Disease Progression with the Huntington's Disease Integrated Staging System (HD-ISS)

Cristina Sampaio et al. J Huntingtons Dis. 2024.
No abstract available

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Conflict of interest statement

Sarah Tabrizi is an Associate Editor and Anne Rosser is an Editorial Board Member of this journal but neither were involved in the peer-review process of the original article or of this editorial nor had access to any information regarding its peer-review.

Figures

Fig. 1
Fig. 1
Figure 1 provides a schematic representation of how the Huntington’s Disease Integrated Staging System (HD-ISS) aligns with the terminology traditionally used in HD research. In this diagram: •Clinical motor diagnosis, or a Diagnostic Confidence Level (DCL) of 4, corresponds to the latter part of HD-ISS stage 2. •The Shoulson and Fahn stages, which are applicable after clinical motor diagnosis and are based on specific Total Functional Capacity (TFC) scores, overlap with the end of HD-ISS stage 2 and encompass all of stage 3. The figure also illustrates various terms used to denote periods before clinical motor diagnosis. While their usage has not been strictly defined, we propose that HD-ISS stages 0 and 1 can be referred to as pre-symptomatic, whereas stages 2 and 3 of the HD-ISS can be considered symptomatic stages.
See this image and copyright information in PMC

References

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