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. 2024;32(5):3217-3230.
doi: 10.3233/THC-231906.

Experimental study using phantom models of cerebral aneurysms and 4D-DSA to measure blood flow on 3D-color-coded images

Soichiro Fujimura  1   2   1 , Yuma Yamanaka  2   3   1 , Issei Kan  4 , Masahiro Nagao  3 , Katharina Otani  4   5 , Kostadin Karagiozov  4 , Koji Fukudome  6 , Toshihiro Ishibashi  4 , Hiroyuki Takao  2   4 , Masahiro Motosuke  1 , Makoto Yamamoto  1 , Yuichi Murayama  4
Affiliations

Experimental study using phantom models of cerebral aneurysms and 4D-DSA to measure blood flow on 3D-color-coded images

Soichiro Fujimura et al. Technol Health Care. 2024.

Abstract

Background: The current 3D-iFlow application can only measure the arrival time of contrast media through intensity values. If the flow rate could be estimated by 3D-iFlow, patient-specific hemodynamics could be determined within the scope of normal diagnostic management, eliminating the need for additional resources for blood flow rate estimation.

Objective: The aim of this study is to develop and validate a method for measuring the flow rate by data obtained from 3D-iFlow images - a prototype application in Four-dimensional digital subtraction angiography (4D-DSA).

Methods: Using phantom model and experimental circuit with circulating glycerin solution, an equation for the relationship between contrast media intensity and flow rate was developed. Applying the equation to the aneurysm phantom models, the derived flow rate was evaluated.

Results: The average errors between the derived flow rate and setting flow rate became larger when the glycerin flow and the X-rays from the X-ray tube of the angiography system were parallel to each other or when the measurement point included overlaps with other contrast enhanced areas.

Conclusion: Although the error increases dependent on the imaging direction and overlap of contrast enhanced area, the developed equation can estimate the flow rate using the image intensity value measured on 3D-iFlow based on 4D-DSA.

Keywords: Aneurysm; four-dimensional digital subtraction angiography; hemodynamics.

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Conflict of interest statement

K. Otani is a full-time employee of Siemens Healthcare. The other authors have no conflicts of interest to report.

Figures

Figure 1.
Figure 1.
Experimental design and phantom models installed in the circuit. (A) Schematic diagram of the experimental circuit with circulating glycerin solution. (B) Detailed design and pictures of the four types of the phantom model (ST-model, I-model, L-model, and U-model).
Figure 2.
Figure 2.
Results of intensity value and flow rate from the 4D-DSA imaging for the ST-model. (A) Time intensity curves (TICs) of the contrast media for 10 flow rates. (B) Relationship between the measured Intensityave and flow rate.
Figure 3.
Figure 3.
Conditions during 4D-DSA imaging in each model. (A) Time intensity curves (TICs) at the measurement point on distal side in the aneurysm phantom model. (B) Geometrical relationship between C-arm position and L-model or U-model depending on the time during the imaging protocol.
Figure 4.
Figure 4.
Relationship between the Intensityave and iodine concentration.
See this image and copyright information in PMC

References

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