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Multicenter Study
. 2024 Jul 5;19(7):e0306056.
doi: 10.1371/journal.pone.0306056. eCollection 2024.

The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study

Tainá Veras de Sandes-Freitas  1   2   3 , Lucio Requião Moura  4   5 , Deise Rosa de Boni Monteiro de Carvalho  6 , Valter Duro Garcia  7 , Luis Gustavo Modelli de Andrade  8 , Marilda Mazzali  9 , Roberto Ceratti Manfro  10 , Luciane Mônica Deboni  11 , Elias Davi-Neto  12 , Claudia Maria Costa de Oliveira  2 , Frederico Castelo Branco Cavalcanti  13 , Rafael Lage Madeira  14 , Ronaldo de Matos Esmeraldo  3 , Denise Rodrigues Simão  15 , Ana Carolina Guedes Meira  16 , Gustavo Fernandes Ferreira  17 , Marcus Lasmar  18 , Alexandre Tortoza Bignelli  19 , Alvaro Pacheco-Silva  20 , José Medina Pestana  4   5 , Hélio Tedesco Silva  4   5 ; DGF-Brazil Study Group
Affiliations
Multicenter Study

The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study

Tainá Veras de Sandes-Freitas et al. PLoS One. .

Abstract

This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.

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Conflict of interest statement

The study received financial support from Contatti Comercio e Representações Ltda, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Figures

Fig 1
Fig 1. Flow chart of study population.
Fig 2
Fig 2. Utilization trends of Euro-Collins (EC), Histidine-tryptophan-ketoglutarate (HTK), and Institut Georges Lopez (IGL-1) for kidney preservation in Brazilian transplant centers.
Fig 3
Fig 3. Incidence of delayed graft function (DGF) and prolonged DGF in the preservation solution groups.
See this image and copyright information in PMC

References

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