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. 2024 Sep 1;47(9):1593-1596.
doi: 10.2337/dc24-0668.

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study

Justine Cole  1 , Claire Guivarch  2   3   4 , Jing Wu  5 , Paulina Stallcup  1 , Wei Wei Pang  2   3   4 , Cuilin Zhang  2   3   4   6 , David B Sacks  1
Affiliations

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study

Justine Cole et al. Diabetes Care. .

Abstract

Objective: To investigate associations of plasma glycated albumin (GA) concentrations in early and midpregnancy with gestational diabetes mellitus (GDM) risk.

Research design and methods: We measured GA concentrations using blood samples collected at 10-14 and 15-26 weeks' gestation in 107 GDM case and 214 control participants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM case and control participants and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk.

Results: At 15-26 weeks' gestation mean GA was lower in GDM case participants than in control participants (mean 11.90% [95% CI 6.42-32.76] vs. 12.46% [8.45-38.35], adjusted P value for difference = 0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant.

Conclusions: This study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

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Conflict of interest statement

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Figures

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Graphical abstract
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References

    1. Petitt DJ, Bennett PH, Knowler WC, Baird HR, Aleck KA. Gestational diabetes mellitus and impaired glucose tolerance during pregnancy. Long-term effects on obesity and glucose tolerance in the offspring. Diabetes 1985;34 Suppl. 2:119–122 - PubMed
    1. HAPO Study Cooperative Research Group; Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991–2002 - PubMed
    1. ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus. Obstet Gynecol 2018;131:e49–e64 - PubMed
    1. ElSayed NA, Aleppo G, Aroda VR, et al.; American Diabetes Association. 15. Management of diabetes in pregnancy: Standards of Care in Diabetes—2023. Diabetes Care 2023;46:S254–S266 - PMC - PubMed
    1. Simmons D, Immanuel J, Hague WM, et al.; TOBOGM Research Group . Treatment of gestational diabetes mellitus diagnosed early in pregnancy. N Engl J Med 2023;388:2132–2144 - PubMed