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Observational Study
. 2024 Jul 5;14(7):e084835.
doi: 10.1136/bmjopen-2024-084835.

Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study protocol: a prospective observational cohort study of reproductive-aged women living with HIV

Deborah Kacanek  1 , Lynn M Yee  2 , Tzy-Jyun Yao  3 , Jessica Lee  3 , Ellen G Chadwick  4 , Paige L Williams  5 , Emily A Barr  6 , Claire A Berman  7 , Mariam Davtyan  8 , Alex DiPerna  9 , Amanda Flores  7 , Jennifer Green  10 , Lisa B Haddad  11 , Laurie Hyzy  9 , Denise L Jacobson  3 , Tamarra James-Todd  7 , Jennifer Jao  4   12 , Anisa Khadraoui  7 , Kathleen M Malee  13 , Anna-Barbara Moscicki  14 , Kunjal Patel  7 , Lisa-Gaye Robinson  15 , Liz Salomon  7 , Kimbrae Sanders  16 , Suzanne Siminski  9 , Renee A Smith  17 , Tracy Wolbach  10 , Kathleen M Powis  18   19 ; Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) Study; Health Outcomes in Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) Study
Collaborators, Affiliations
Observational Study

Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study protocol: a prospective observational cohort study of reproductive-aged women living with HIV

Deborah Kacanek et al. BMJ Open. .

Abstract

Introduction: Over 265 000 women are living with HIV in the USA, but limited research has investigated the physical, mental and behavioural health outcomes among women living with HIV of reproductive age. Health status during the reproductive years before, during and after pregnancy affects pregnancy outcomes and long-term health. Understanding health outcomes among women living with HIV of reproductive age is of substantial public health importance, regardless of whether they experience pregnancy. The Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study is a prospective observational cohort study designed to investigate physical and mental health outcomes of young women living with HIV as they age, including HIV disease course, engagement in care, reproductive health and choices and cardiometabolic health. We describe the HOPE study design, and characteristics of the first 437 participants enrolled as of 1 January 2024.

Methods and analysis: The HOPE study seeks to enrol and follow 1630 women living with HIV of reproductive age, including those with perinatally-acquired HIV, at 12 clinical sites across 9 US states and Puerto Rico. HOPE studies multilevel dynamic determinants influencing physical, mental and social well-being and behaviours of women living with HIV across the reproductive life course (preconception, pregnancy, post partum, not or never-pregnant), informed by the socioecological model. Key research areas include the clinical course of HIV, relationship of HIV and antiretroviral medications to reproductive health, pregnancy outcomes and comorbidities and the influence of racism and social determinants of health. HOPE began enrolling in April 2022.

Ethics and dissemination: The HOPE study received approval from the Harvard Longwood Campus Institutional Review Board, the single institutional review board of record for all HOPE sites. Results will be disseminated through conference presentations, peer-reviewed journals and lay summaries.

Keywords: HIV & AIDS; Health Equity; MENTAL HEALTH; Observational Study; Postpartum Women; Pregnant Women.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals conceptual model. ART, antiretroviral therapy; VL, viral load.
Figure 2
Figure 2
Geographical locations of HOPE study sites across the USA and Puerto Rico. States in darker shade are locations of Pediatric HIV/AIDS Cohort Study sites. HOPE, Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals.
See this image and copyright information in PMC

References

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