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Review
. 2024 Jul 5;24(1):236.
doi: 10.1186/s12935-024-03426-x.

The role of lncRNA NEAT1 in human cancer chemoresistance

Feng Long #  1 , Xue Li #  1 , Jingyu Pan  1 , Hailin Ye  1 , Cuixia Di  2 , Yong Huang  1 , Jiawei Li  1 , Xuan Zhou  1 , Huiyi Yi  1 , Qiaozhen Huang  1 , Jing Si  3
Affiliations
Review

The role of lncRNA NEAT1 in human cancer chemoresistance

Feng Long et al. Cancer Cell Int. .

Abstract

Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become an urgent problem to be solved in the field of cancer chemotherapy. Therefore, it is very important to deeply study and analyze the mechanism of cancer chemotherapy resistance and its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) has been shown to be closely associated with chemotherapy resistance in cancer. NEAT1 induces cancer cell resistance to chemotherapeutic drugs by regulating cell apoptosis, cell cycle, drug transport and metabolism, DNA damage repair, EMT, autophagy, cancer stem cell characteristics, and metabolic reprogramming. This indicates that NEAT1 may be an important target to overcome chemotherapy resistance and is expected to be a potential biomarker to predict the effect of chemotherapy. This article summarizes the expression characteristics and clinical characteristics of NEAT1 in different cancers, and deeply discusses the regulatory role of NEAT1 in cancer chemotherapy resistance and related molecular mechanisms, aiming to clarify NEAT1 as a new target to overcome cancer chemotherapy resistance and the feasibility of chemotherapy sensitizers, with a view to providing a potential therapeutic direction for overcoming the dilemma of cancer resistance in the future.

Keywords: Cancer; Chemotherapy resistance; Mechanism of action; NEAT1.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The function of lncRNA. (a) decoy molecule. (b) guide molecule. (c) signal molecule. (d) scaffold molecule
Fig. 2
Fig. 2
Biogenesis of NEAT1. (A) Location of NEAT1-1 and NEAT1-2 at the MEN site. (B) paraspeckle proteins(PSP) participates in the synthesis of a single NEAT1-2 ribonucleoprotein complex and a paraspeckle model
Fig. 3
Fig. 3
Mechanisms of NEAT1 in cancer. (a) Mediating epigenetic modification. (b) Regulating protein activity. (c) Regulate target gene transcription. (d) Regulate the stability of mRNA. (e) Sponge miRNA. (f) NEAT1 participates in the biological processes of cancer
Fig. 4
Fig. 4
The mechanism of NEAT1 mediated cancer chemotherapy resistance
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