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. 2024 Sep 26;13(9):493-495.
doi: 10.1093/jpids/piae071.

Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case-Control Study

Alice Pascault  1 , Bérengère Koehl  1   2   3 , Valentine Brousse  1   2   3 , Malika Benkerrou  1   2 , Jean Gaschignard  4   5
Affiliations

Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case-Control Study

Alice Pascault et al. J Pediatric Infect Dis Soc. .

Abstract

Hydroxyurea decreases painful events among children with sickle cell disease (SCD) but could increase the risk of infections in treated patients through leucopenia. We performed a case-control study, comparing hydroxyurea treatment for SCD in cases with an invasive bacterial infection and in controls without infection. No difference was found.

Keywords: early treatment; hydroxyurea; invasive bacterial infections; sickle cell disease; spleen function.

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