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. 2024 Aug;28(8):100312.
doi: 10.1016/j.jnha.2024.100312. Epub 2024 Jul 5.

Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study

Virginia Lope  1 , Ángel Guerrero-Zotano  2 , Nerea Fernández de Larrea-Baz  3 , Silvia Antolín  4 , Marta Benavent Viñuales  5 , Begoña Bermejo  6 , Emma Ruiz-Moreno  7 , José Manuel Baena-Cañada  8 , Lorena París  9 , Antonio Antón  10 , José Ignacio Chacón  11 , Montserrat Muñoz  12 , José Angel García-Sáenz  13 , Clara Olier  14 , Pedro Sánchez Rovira  15 , Angels Arcusa Lanza  16 , Sonia González  17 , Joan Brunet  18 , Amparo Oltra  19 , Susana Bezares  20 , Libertad Rosell  20 , Beatriz Pérez-Gómez  3 , Roberto Pastor-Barriuso  7 , Miguel Martín  21 , Marina Pollán  3
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Free article

Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study

Virginia Lope et al. J Nutr Health Aging. 2024 Aug.
Free article

Abstract

Objectives: Adherence to healthy lifestyle recommendations has been reported to improve health-related quality of life (HRQL) in breast cancer (BC) patients, but the influence of long-term behavioral changes remains unknown. We evaluated the association between adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations and HRQL both, at BC diagnosis and the change 7-12 years later.

Design: Prospective cohort study.

Settings and participants: A total of 406 breast cancer survivors, from the EpiGEICAM study, were recruited in 16 Spanish hospitals.

Measurements: Epidemiological, clinical, dietary, physical activity and HRQL information was collected both at recruitment and 7-12 years later. A 7-item score to measure compliance with recommendations was assessed according to the 2018 WCRF/AICR scoring criteria. HRQL was evaluated using SF-36 questionnaire. Linear mixed models for longitudinal data were used to assess the cross-sectional and longitudinal association between adherence score and the physical and mental component summary scores.

Results: At diagnosis, for each unit increase in WCRF/AICR score adherence, the HRQL physical domain increased 0.78 points (95%CI: -0.04 to 1.60; P trend:0.06). The mean change in physical HRQL from diagnosis to follow-up per unit increase in within-subject adherence score was 0.73 points (95%CI: -0.18 to 1.65; P trend: 0.12). For the mental domain, no association was observed with compliance with the recommendations at diagnosis, nor with changes in adherence over time.

Conclusions: Our results suggest that Increased adherence to WCRF/AICR cancer prevention recommendations over time could contribute to slightly improved long-term physical HRQoL in BC survivors.

Keywords: Breast cancer survivors; Cancer prevention guidelines; Health behaviors; Health-related quality of life; WCRF/AICR recommendations.

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