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. 1979 Jun 15;56(3):261-4.
doi: 10.1016/0014-2999(79)90180-8.

Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

P A Fredrickson, E Richelson

Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

P A Fredrickson et al. Eur J Pharmacol. .

Abstract

Hallucinogens were competitive antagonists of histamine at the H1-receptor of cultured mouse neuroblastoma cells. Their rank order of potency at this receptor was similar to that for their potency at eliciting subjective effects in vivo. Comparison with studies of other receptors, however, suggests that no single model of drug--receptor interaction adequately accounts for the known subjective effects of these compounds.

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