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. 2025 Jan;36(1):11-14.
doi: 10.1016/j.tem.2024.06.007. Epub 2024 Jul 6.

Ceramides in the central control of metabolism

Miguel López  1 , Carlos Diéguez  2 , Manuel Tena-Sempere  3 , Ismael González-García  4
Affiliations

Ceramides in the central control of metabolism

Miguel López et al. Trends Endocrinol Metab. 2025 Jan.

Abstract

Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.

Keywords: ceramides; food intake; glucose metabolism; hypothalamus; thermogenesis.

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Conflict of interest statement

Declaration of interests Authors declare no competing interests.

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