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. 2024 Jun 28;21(6):658-668.
doi: 10.26599/1671-5411.2024.06.006.

Association between stress hyperglycemia ratio and in-hospital outcomes: findings from the improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) Project

Wen-Jie Wang  1 , Ke-Xin Wang  1 , Jia-Long Niu  1 , Yi-Xuan Liu  1 , Hai-Long Ge  1 , Hua Shen  1 ; CCC-ACS investigators
Affiliations

Association between stress hyperglycemia ratio and in-hospital outcomes: findings from the improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) Project

Wen-Jie Wang et al. J Geriatr Cardiol. .

Abstract

Background: Stress hyperglycemia ratio (SHR) could provide accurate information on the acute status of hyperglycemia. The relationship between SHR and acute coronary syndrome (ACS) prognosis remains unclear. This study was conducted to identity the association between SHR and in-hospital outcomes in patients with ACS.

Methods: A total of 12,010 patients were eventually enrolled in the study. The relationship between SHR and in-hospital major adverse cardiovascular events (MACEs) was then modeled by restricted cubic spline (RCS) curves, and all patients were divided into three groups according to the results. The multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes, described as odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were also performed on different diseases.

Results: The median age of this cohort was 63 (54, 71) years old, and 8942 (74.5%) were male. Group 1 was defined as SHR < 0.6 (n = 426), Group 2 was defined as SHR between 0.6 and 1 (n = 5821), and Group 3 was defined as SHR > 1 (n = 5763). Compared with Group 2, Group 1 (OR = 1.891, 95% CI: 1.028-3.479, P < 0.001) and Group 3 (OR = 1.868, 95% CI: 1.434-2.434, P < 0.001) had higher risks of suffering from in-hospital MACEs. SHR was associated with higher risks of in-hospital MACEs in the subgroups of DM [OR = 2.282, 95% CI: 1.477-3.524).

Conclusions: Both low and high SHR levels were independently associated with in-hospital MACEs. Young males with DM, hypertension, and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The flow chart.
Figure 2
Figure 2
Restricted cubic spline analysis.
Figure 3
Figure 3
The pie chart of the composition of the major adverse cardiovascular events in all ACS patients.
Figure 4
Figure 4
The subgroup analysis of associations between SHR and MACEs.
See this image and copyright information in PMC

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References

    1. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736-1788.

    1. Ralapanawa U, Sivakanesan R Epidemiology and the magnitude of coronary artery disease and acute coronary syndrome: a narrative review. J Epidemiol Glob Health. 2021;11:169–177. doi: 10.2991/jegh.k.201217.001. - DOI - PMC - PubMed
    1. Dziewierz A, Giszterowicz D, Siudak Z, et al Admission glucose level and in-hospital outcomes in diabetic and non-diabetic patients with acute myocardial infarction. Clin Res Cardiol. 2010;99:715–721. doi: 10.1007/s00392-010-0175-1. - DOI - PubMed
    1. Marik PE, Bellomo R Stress hyperglycemia: an essential survival response! Crit Care. 2013;17:305. - PMC - PubMed
    1. Capes SE, Hunt D, Malmberg K, et al Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32:2426–2432. doi: 10.1161/hs1001.096194. - DOI - PubMed

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