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. 2024 Jul 3:17:3091-3100.
doi: 10.2147/JMDH.S458528. eCollection 2024.

Placental and Neonatal Serum Leptin Levels in Premature Infants After Phototherapy: Are They Determining Factors for the Safe Indication of Passive Exercises?

Samira Said Lançoni  1   2 , Jocilene Pedroso Albuquerque  1   3 , Adriane Muller Nakato  2 , Gislayne Castro E Souza de Nieto  4 , Cláudio Marcelo Tkac  5 , Marcos Fabiano Sigwalt  1   3 , Percy Nohama  2 , Larissa Riskalla Talamini Souto  2 , Paulo Afonso Nunes Nassif  1   3
Affiliations

Placental and Neonatal Serum Leptin Levels in Premature Infants After Phototherapy: Are They Determining Factors for the Safe Indication of Passive Exercises?

Samira Said Lançoni et al. J Multidiscip Healthc. .

Abstract

Purpose: To analyze leptin levels in placental tissue and premature infants undergoing phototherapy and to evaluate the potential for prescribing passive exercise after phototherapy in this population.

Patients and methods: This analytical, longitudinal, prospective cohort study included 108 parturients and their respective premature infants. Variables examined included weight, gestational age, body mass index, sex, serum leptin levels in placental tissue, serum bilirubin levels, and reticulocyte count.

Results: When comparing each group to a leptin threshold, statistically significant differences were observed at all evaluated time points for placental leptin levels (p < 0.001). Additionally, reticulocyte count decreased in relation to rebound time (p < 0.004). No correlations were found between leptin/bilirubin levels, leptin/reticulocytes, onset of nutrition, and BMI/leptin levels.

Conclusion: The findings regarding leptin levels suggest that prescribing passive exercises to premature infants undergoing phototherapy may be feasible because this intervention did not increase leptin levels.

Keywords: child obesity; hyperbilirubinemia; leptin; neonatal intensive care unit; prematurity.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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Flowchart of the patients.
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