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. 2024 Jun;74(3):250-255.
doi: 10.1007/s13224-023-01903-3. Epub 2024 Feb 14.

To Evaluate the Efficacy and Safety of Mifepristone in Reducing the Size & Symptoms of Uterine Leiomyoma/Fibroids

Suruchi Desai  1 , Shreya Oswal  1 , Chirag Patel  1 , Rashmi Parikh  2
Affiliations

To Evaluate the Efficacy and Safety of Mifepristone in Reducing the Size & Symptoms of Uterine Leiomyoma/Fibroids

Suruchi Desai et al. J Obstet Gynaecol India. 2024 Jun.

Abstract

Background and study objective: Uterine leiomyomas, or fibroids, are prevalent benign gynecological tumors affecting many women during their reproductive years. While surgical excision has long been the gold standard for fibroid treatment, the pharmacological management, including progesterone receptor modulators like mifepristone (RU 486), has garnered attention due to the reduced surgical approaches. However, there is a notable paucity of research on the effectiveness of mifepristone, on the same. This study seeks to evaluate the safety and efficacy of mifepristone in reducing uterine leiomyoma size and alleviating associated symptoms.

Methodology: Conducted prospectively, the study enrolled 20 pre-menopausal women, aged 18 years or older, from Nanavati Max Super Speciality Hospital Mumbai, Maharashtra, India. Participants were selected based on specific inclusion criteria, including the presence of at least one uterine myoma with a minimum diameter of 2.5 cm as confirmed by ultrasound. Participants had an average age of 39.75 years and an average BMI of 27.58 kg/m2.

Results: The study found that mifepristone significantly reduced uterine volume by 75%, with hemoglobin levels substantially improving from 9 gm/dL initially to 12.51 gm/dL after six months. Pain intensity, assessed using the Visual Analog Scale (VAS) score, gradually decreased from baseline to three-month, with all 20 patients reporting the complete absence of pelvic pain by six months.

Conclusion: This prospective study highlights mifepristone's promise as a non-surgical approach to effectively reduce uterine fibroid volume, improve hemoglobin levels, and mitigate uterine blood loss in patients.

Keywords: Leiomyomas; Mifepristone; Uterine fibroids; Uterine volume; Visual analog score.

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Conflict of interest statement

Conflict of interestNo conflict of interest.

Figures

Fig. 1
Fig. 1
Mean hemoglobin levels at different visits
Fig. 2
Fig. 2
VAS score of pelvic pain at different visits
Fig. 3
Fig. 3
VAS score of pressure symptoms at different visits
See this image and copyright information in PMC

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References

    1. Adamson GD. Treatment of uterine fibroids current findings with gonadotrophin releasing hormone agonists. Am J Obstet Gynecol. 1992;166:746–751. doi: 10.1016/0002-9378(92)91707-H. - DOI - PubMed
    1. Prusty RK, Choithani C, Gupta SD. Predictors of hysterectomy among married women 15–49 years in India. Reprod Health. 2018;15(1):3. doi: 10.1186/s12978-017-0445-8. - DOI - PMC - PubMed
    1. Carlson KJ, Nichols DH, Schiff I. Indications of hysterectomy. N Engl J Med. 1993;328:856–860. doi: 10.1056/NEJM199303253281207. - DOI - PubMed
    1. Cardozo ER, Segars JH, Banks BJ, Henne MB, Stregman BJ. The estimated annual cost of uterine myoma in United Sates. Am J Obstet Gynecol. 2012;206(211):e1–9. - PMC - PubMed
    1. Delco V, la Marca A, Margante G. Short term treatment of uterine fibromyomas with danazol gynecol. Obstet Invest. 1999;47:258–262. doi: 10.1159/000010118. - DOI - PubMed

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