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Review
. 2024 Oct 1;37(5):431-435.
doi: 10.1097/QCO.0000000000001019. Epub 2024 Jul 4.

H5 and H9 avian influenza - potential re-emergent zoonotic threats to humans

Gavin Dabrera  1
Affiliations
Review

H5 and H9 avian influenza - potential re-emergent zoonotic threats to humans

Gavin Dabrera. Curr Opin Infect Dis. .

Abstract

Purpose of review: This review aims to discuss the current state of human infections with Avian Influenza A (H5) and (H9) viruses, to support awareness of the global epidemiology among clinicians and public health professionals interested in emerging respiratory infections.

Recent findings: Among increasing numbers of detections in avian species of Avian Influenza A(H5N1) clade 2.3.4.4b globally, reported human cases of severe infection have been rare.Enhanced surveillance of persons exposed to avian species infected with Influenza A (H5N1) clade 2.3.4.4b in different countries has identified small numbers of asymptomatic individuals with Avian Influenza A (H5N1) detected by PCR from the upper respiratory tract; some of these instances have been considered to represent contamination rather than infection.There have also been recent sporadic human cases of Avian Influenza A(H9N2) internationally, including in China and Cambodia.

Summary: Human infections with Avian Influenza A(H5) and (H9) viruses remain of interest as an emerging infection both to clinicians and public health professionals. While maintaining effective surveillance is essential, one health strategies to control infection in avian species will be key to mitigating these risks.

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References

    1. Olsen SJ, Ungchusak K, Sovann L, et al. Family clustering of Avian Influenza A (H5N1). Emerg Infect Dis 2005; 11:1799–1801.
    1. Kandun IN, Wibisono H, Sedyaningsih ER, et al. Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med 2006; 355:2186–2194.
    1. Yu H, Feng Z, Zhang X, et al. Human Influenza A (H5N1) cases, urban areas of People's Republic of China, 2005-2006. Emerg Infect Dis 2007; 13:1061–1064.
    1. Neuzil KM, Anderson EJ, Frenck RW, et al. Safety and immunogenicity of influenza A/H5N8 virus vaccine in healthy adults: durability and cross-reactivity of antibody responses. Clin Infect Dis 2023; ciac982 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac982/696... - DOI
    1. Vesikari T, Forstén A, Herbinger KH, et al. Safety and immunogenicity of an MF59 ® -adjuvanted A/H5N1 prepandemic influenza vaccine in adults and the elderly. Vaccine 2012; 30:1388–1396.

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