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. 2024 Jul 8:1-9.
doi: 10.1080/14786419.2024.2372847. Online ahead of print.

Aframomumlabdane, a new bislabdane diterpenoid from Aframomum arundinaceum ( zingiberaceae)

Patrick Y Ango  1 , Arlette W Ghoda  2 , Destaing F Abega  2 , Renameditswe Mapitse  3 , Victor Kuete  4 , Bonaventure T Ngadjui  2 , Ghislain W Fotso  2 , Deccaux W F G Kapche  5
Affiliations

Aframomumlabdane, a new bislabdane diterpenoid from Aframomum arundinaceum ( zingiberaceae)

Patrick Y Ango et al. Nat Prod Res. .

Abstract

A previously undescribed bislabdane diterpenoid namely aframomumlabdane (1), was isolated from the seed of Aframomum arundinaceum together with seven known compounds (2 - 8). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound 1 was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1. The best activity was observed against SPC212 lung cancer cell line with an IC50 value of 0.52 μM.

Keywords: Aframomum arundinaceum; aframomumlabdane; bislabdane; cytotoxicity activity; diterpenoid; zingiberaceae.

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