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Practice Guideline
. 2024 Sep;36(9):e13423.
doi: 10.1111/jne.13423. Epub 2024 Jul 8.

European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours

Angela Lamarca  1   2 , Detlef K Bartsch  3 , Martyn Caplin  4 , Beata Kos-Kudla  5 , Andreas Kjaer  6 , Stefano Partelli  7 , Anja Rinke  8 , Eva Tiensuu Janson  9 , Christina Thirlwell  10 , Marie-Louise F van Velthuysen  11 , Marie-Pierre Vullierme  12 , Marianne Pavel  13
Affiliations
Practice Guideline

European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours

Angela Lamarca et al. J Neuroendocrinol. 2024 Sep.

Abstract

Both the incidence and prevalence of well-differentiated neuroendocrine tumours from the small intestine (Si-NET) are gradually increasing. Most patients have non-functioning tumours with subtle GI symptoms and tumours are often discovered incidentally by endoscopy or at advanced disease stages by imaging depicting mesenteric lymph node and /or liver metastases while around 30% of the patients present with symptoms of the carcinoid syndrome. Adequate biochemical assessment and staging including functional imaging is crucial for treatment-related decision-making that should take place in an expert multidisciplinary team setting. Preferably, patients should be referred to specialised ENETS Centres of Excellence or centres of high expertise in the field. This guidance paper provides the current evidence and best knowledge for the management of Si-NET grade (G) 1-3 following 10 key questions of practical relevance for the diagnostic and therapeutic decision making.

Keywords: guidance; neuroendocrine; small intestine; treatment.

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References

REFERENCES

    1. Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3(10):1335‐1342.
    1. Sorbye H, Grande E, Pavel M, et al. European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma. J Neuroendocrinol. 2023;35(3):e13249.
    1. WHO. WHO classification of tumours of the digestive system. 2022. https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-O....
    1. WHO. WHO classification of tumours of endocrine organs – IARC. 2022. https://www.iarc.who.int/news-events/who-classification-of-tumours-of-en....
    1. Fraenkel M, Kim M, Faggiano A, de Herder WW, Valk GD. Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature. Endocr Relat Cancer. 2014;21(3):R153‐R163.

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