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. 2024:2816:139-144.
doi: 10.1007/978-1-0716-3902-3_13.

Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling

Jawad Muayad  1 , Maria D Cabrera Gonzalez  2   3
Affiliations

Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling

Jawad Muayad et al. Methods Mol Biol. 2024.

Abstract

Phosphatidic acid (PA) is a key signaling lipid that plays a crucial role in regulating various cellular processes. Studies have shown that azobenzene-containing PA analogues can be used as an all-chemical strategy for light-mediated control of PA signaling. These photoswitchable lipids offer a solution to the limitations of traditional bulk dosing methods by allowing for light- and shape-dependent interactions with protein effectors and lipid-metabolizing enzymes. This chapter describes how to synthesize AzoPA and dAzoPA.

Keywords: Azo-analogs; Phosphatidic acid; Photoswitchable.

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