Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling
- PMID: 38977595
- DOI: 10.1007/978-1-0716-3902-3_13
Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling
Abstract
Phosphatidic acid (PA) is a key signaling lipid that plays a crucial role in regulating various cellular processes. Studies have shown that azobenzene-containing PA analogues can be used as an all-chemical strategy for light-mediated control of PA signaling. These photoswitchable lipids offer a solution to the limitations of traditional bulk dosing methods by allowing for light- and shape-dependent interactions with protein effectors and lipid-metabolizing enzymes. This chapter describes how to synthesize AzoPA and dAzoPA.
Keywords: Azo-analogs; Phosphatidic acid; Photoswitchable.
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
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