Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jun;116(3):176-179.
doi: 10.32074/1591-951X-974.

Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis

Antonio Travaglino  1   2 , Angela Santoro  1   3 , Damiano Arciuolo  1   3 , Giulia Scaglione  1 , Antonio Raffone  4 , Alessia Piermattei  1 , Maria Elisabetta Onori  5 , Angelo Minucci  5 , Luigi Pedone Anchora  6 , Francesco Fanfani  3   6 , Gian Franco Zannoni  1   3
Affiliations
Case Reports

Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis

Antonio Travaglino et al. Pathologica. 2024 Jun.

Abstract

A corded and hyalinized pattern has been described in endometrial endometrioid carcinoma. Herein, we describe a clinicopathological and molecular analysis of the first reported case of endometrial serous carcinoma with a corded and hyalinized pattern.

A 64-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy due to a 5.5 cm endometrial lesion. Histologically, the tumor was composed of a minor (20%) serous carcinoma component and a predominant corded component embedded in a hyaline-to-myxoid matrix. This component showed diffuse and strong p53 and p16 expression, heterogeneous positivity for epithelial markers and WT1, focal positivity for estrogen and progesterone receptors, retained MMR, SMARCA4/BRG1, and SMARCB1/INI1 expression, and negativity for smooth muscle, germ cell, sex cord, neuroendocrine, endothelial, and melanocytic markers and GATA3. Next-generation sequencing showed a mutation of uncertain significance in APC and no mutations in MLH1, MSH2, MSH6, PMS2, MUTYH, POLE, POLD1, EPCAM, or CTNNB1. The patient had a recurrence on the vaginal stump after 15 months.

In conclusion, endometrial serous carcinoma can show a corded and hyalinized pattern, which may represent a diagnostic challenge.

Keywords: corded and hyalinized; endometrial carcinoma; immunohistochemical; molecular; serous carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
(A) Coexistence of serous component (left) and corded and hyalinized component (right). (B) Cords of relatively uniform atypical cells with a high nucleus-to-cytoplasm ratio, immersed in a hyaline-to-myxoid stroma. (C) Area of positivity for cytokeratin-AE1/AE3. (D) Membrane β-catenin expression with no cytoplasmic/nuclear accumulation. (E) Overexpression of p53 (mutation-type pattern). (F) Strong and diffuse p16 positivity (block-type pattern).
See this image and copyright information in PMC

References

    1. WHO Classification of Tumours Editorial Board. Female Genital Tumours. Lyon (France): International Agency for Research on Cancer; 2020. (WHO classification of tumours series, 5th ed.; vol. 4)
    1. Santoro A, Angelico G, Travaglino A, et al. . New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines. Cancers (Basel). 2021;13(11):2623.doi:10.3390/cancers13112623 10.3390/cancers13112623 - DOI - PMC - PubMed
    1. Abu-Rustum NR, Yashar CM, Bradley K, et al. . NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) – Uterine neoplasms. Version 1.2022 – November 4,2021. https://doi.org/10.6004/jnccn.2021.0038 10.6004/jnccn.2021.0038. - DOI
    1. Murray SK, Clement PB, Young RH. Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms. Am J Surg Pathol. 2005;29(2):157-66. https://doi.org/10.1097/01.pas.0000149704.89463.05 10.1097/01.pas.0000149704.89463.05. - DOI - PubMed
    1. Wani Y, Saegusa M, Notohara K. Aberrant nuclear beta-catenin expression in the spindle or corded cells in so-called corded and hyalinized endometrioid carcinomas. Another critical role of the unique morphological feature. Histol Histopathol. 2009;24(2):149-55. https://doi.org/10.14670/HH-24.149 10.14670/HH-24.149. - DOI - PubMed

Publication types

Substances

LinkOut - more resources