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. 1985 May;33(5):368-72.

[Transplacental transfer of 5 antibiotics by in vitro human placental perfusion]

[Article in French]
J P Akbaraly, S Guibert, J J Leng, J Auzerie
  • PMID: 3897968

[Transplacental transfer of 5 antibiotics by in vitro human placental perfusion]

[Article in French]
J P Akbaraly et al. Pathol Biol (Paris). 1985 May.

Abstract

Transplacental transfer of 5 semi-synthetic penicillins which act on Gram + and Gram - bacteria were studied by in vitro perfusion of the human placenta. These penicillins were: amoxicillin, apalcillin, mezlocillin, piperacillin and ticarcillin. Placental transfer of these 5 antibiotics varies between 5 and 7% of the maternal concentration. Amoxicillin 7,62% - apalcillin 5,66% - mezlocillin 5,4% - piperacillin 7,37% - ticarcillin 4,86%. The reasons for such low transfer and the clinical repercussions of these results are discussed by the authors.

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