Incidence and risk factors of cutaneous reactions to the first COVID-19 booster vaccine

Liam R Smith¹, Ruchi J Shah¹, Andrew J King^{1

2}, Erica S Shenoy^{2

3

4}, Adam B Landman^{2

5}, Dean M Hashimoto^{2

6}, Kimberly Blumenthal^{1

2}

Affiliations

¹ Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
² Harvard Medical School, Boston, Massachusetts, USA.
³ Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Infection Control Unit, Mass General Brigham, Boston, Massachusetts, USA.
⁵ Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁶ Occupational Health Services, Mass General Brigham, Boston, Massachusetts, USA.

Liam R Smith et al. Allergy. 2025 Feb.

. 2025 Feb;80(2):575-578.

doi: 10.1111/all.16223. Epub 2024 Jul 9.

Liam R Smith¹, Ruchi J Shah¹, Andrew J King^{1

2}, Erica S Shenoy^{2

3

4}, Adam B Landman^{2

5}, Dean M Hashimoto^{2

6}, Kimberly Blumenthal^{1

2}

¹ Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
² Harvard Medical School, Boston, Massachusetts, USA.
³ Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Infection Control Unit, Mass General Brigham, Boston, Massachusetts, USA.
⁵ Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁶ Occupational Health Services, Mass General Brigham, Boston, Massachusetts, USA.

No abstract available

Keywords: allergy; angioedema; hives; hypersensitivity; mRNA; rash; skin; vaccine.

References

1. World Health Organization. WHO Coronavirus (COVID‐19) Dashboard. 2021 https://covid19.who.int/.
1. Rzymski P, Poniedziałek B, Fal A. Willingness to receive the booster COVID‐19 vaccine dose in Poland. Vaccines (Basel). 2021;9:1286.
1. Freeman EE, Strahan AG, Smith LR, et al. The impact of coronavirus disease 2019 (COVID‐19) vaccine reactions on secondary vaccine hesitancy. Ann Allergy Asthma Immunol. 2024;15:630‐636. doi:10.1016/j.anai.2024.01.009
1. Robinson LB, Fu X, Hashimoto D, et al. Incidence of cutaneous reactions after messenger RNA COVID‐19 vaccines. JAMA Dermatol. 2021;157(8):1000‐1002. doi:10.1001/jamadermatol.2021.2114
1. Judd A, Samarakoon U, Blumenthal K. Self‐reported reactions after COVID‐19 vaccination. J Allergy Clin Immunol. 2022;149(2):AB56. doi:10.1016/j.jaci.2021.12.216