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. 2024 Aug 1;5(8):1197-1199.
doi: 10.34067/KID.0000000000000499. Epub 2024 Jul 9.

Minimal Change Disease and FSGS Are a Spectrum of a Single Disease within Immune-Mediated Nephrotic Syndrome

Affiliations

Minimal Change Disease and FSGS Are a Spectrum of a Single Disease within Immune-Mediated Nephrotic Syndrome

John J Sim et al. Kidney360. .
No abstract available

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Conflict of interest statement

Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/KN9/A557.

Figures

Figure 1
Figure 1
Within immune-mediated NS, the histologic lesions of MCD and primary FSGS represent a common pathologic process and a single clinical disease entity. MCD may be diagnosed earlier during the podocytopathy when sclerosis is less evident. With disease progression, podocyte loss and sclerosis of glomeruli become more prevalent, which also increases the likelihood of detecting FSGS in a biopsy sample. MCD, minimal change disease; NS, nephrotic syndrome.

References

    1. Hommos MS De Vriese AS Alexander MP, et al. . The incidence of primary vs secondary focal segmental glomerulosclerosis: a clinicopathologic study. Mayo Clin Proc. 2017;92(12):1772–1781. doi:10.1016/j.mayocp.2017.09.011 - DOI - PMC - PubMed
    1. Schachter AD. Computational simulation of renal biopsy accuracy in focal segmental glomerulosclerosis. Pediatr Nephrol. 2006;21(7):953–957. doi:10.1007/s00467-006-0127-1 - DOI - PMC - PubMed
    1. Canaud G Dion D Zuber J, et al. . Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS). Nephrol Dial Transplant. 2010;25(4):1321–1328. doi:10.1093/ndt/gfp500 - DOI - PubMed
    1. Hayslett JP, Krassner LS, Bensch KG, Kashgarian M, Epstein FH. Progression of “lipoid nephrosis” to renal insufficiency. N Engl J Med. 1969;281(4):181–187. doi:10.1056/nejm196907242810402 - DOI - PubMed
    1. Tarshish P, Tobin JN, Bernstein J, Edelmann CM, Jr. Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol. 1997;8(5):769–776. doi:10.1681/ASN.V85769 - DOI - PubMed

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