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. 2024 Jul 9;111(3):622-626.
doi: 10.4269/ajtmh.23-0873. Print 2024 Sep 4.

Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia

Ayzsa Tannis  1   2 , Suzanne Newton  1 , Angelica Rico  3 , Maritza Gonzalez  3 , Monica Benavides  4 , Jessica N Ricaldi  5 , Helena Rodriguez  3 , Laura D Zambrano  6 , Marcela Daza  4 , Shana Godfred-Cato  1 , Jennifer D Thomas  5 , Jacqueline Acosta  7 , Panagiotis Maniatis  6 , Jonathan B Daniels  8 , Veronica Burkel  1   2 , Elizabeth C Ailes  1 , Diana Valencia  5 , Suzanne M Gilboa  1 , Denise J Jamieson  9 , Marcela Mercado  4 , Julie M Villanueva  5 , Margaret A Honein  5 , Martha L Ospina  10   11 , Van T Tong  1
Affiliations

Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia

Ayzsa Tannis et al. Am J Trop Med Hyg. .

Abstract

Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (n = 1,519) during February 2017-September 2018 and their infants (n = 1,080) during June 2017-March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3-7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7-2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.

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